Reaction Details | |||
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Target | Gamma-aminobutyric acid receptor subunit beta-3 | ||
Ligand | BDBM50214659 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_448071 (CHEMBL898326) | ||
Ki | 1.9±n/a nM | ||
Citation | Alam, MS; Huang, J; Ozoe, F; Matsumura, F; Ozoe, Y Synthesis, 3D-QSAR, and docking studies of 1-phenyl-1H-1,2,3-triazoles as selective antagonists for beta3 over alpha1beta2gamma2 GABA receptors. Bioorg Med Chem15:5090-104 (2007) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Gamma-aminobutyric acid receptor subunit beta-3 | |||
Name: | Gamma-aminobutyric acid receptor subunit beta-3 | ||
Synonyms: | GABA A receptor alpha-4/beta-3/gamma-2 | GABA receptor beta-3 subunit | GABA-A receptor | GABRB3 | GBRB3_HUMAN | agonist GABA site | ||
Type: | PROTEIN | ||
Mol. Mass.: | 54130.51 | ||
Organism: | Homo sapiens (Human) | ||
Description: | ChEMBL_448071 | ||
Residue: | 473 | ||
Sequence: |
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BDBM50214659 | |||
n/a | |||
Name | BDBM50214659 | ||
Synonyms: | 1-(2,6-dichloro-4-trifluoromethylphenyl)-5-methyl-4-n-propyl-1H-1,2,3-triazole | CHEMBL236471 | ||
Type | Small organic molecule | ||
Emp. Form. | C13H12Cl2F3N3 | ||
Mol. Mass. | 338.156 | ||
SMILES | CCCc1nnn(c1C)-c1c(Cl)cc(cc1Cl)C(F)(F)F |(3.52,-8.6,;2.27,-7.69,;2.44,-6.16,;1.2,-5.26,;1.2,-3.72,;-.27,-3.23,;-1.17,-4.48,;-.27,-5.73,;-.75,-7.19,;-2.71,-4.48,;-3.47,-5.81,;-2.69,-7.14,;-5,-5.82,;-5.78,-4.48,;-5.01,-3.14,;-3.47,-3.14,;-2.7,-1.81,;-7.32,-4.48,;-8.87,-4.54,;-7.36,-2.94,;-7.27,-6.02,)| | ||
Structure |