Reaction Details |
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Target | Melanocortin receptor 4 |
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Ligand | BDBM50214689 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_448087 (CHEMBL898343) |
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Ki | 1.8±n/a nM |
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Citation | Tran, JA; Tucci, FC; Jiang, W; Marinkovic, D; Chen, CW; Arellano, M; Markison, S; Fleck, BA; Wen, J; White, NS; Pontillo, J; Saunders, J; Marks, D; Hoare, SR; Madan, A; Foster, AC; Chen, C Pyrrolidinones as orally bioavailable antagonists of the human melanocortin-4 receptor with anti-cachectic activity. Bioorg Med Chem15:5166-76 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Melanocortin receptor 4 |
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Name: | Melanocortin receptor 4 |
Synonyms: | MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R) |
Type: | Enzyme |
Mol. Mass.: | 36949.50 |
Organism: | Homo sapiens (Human) |
Description: | P32245 |
Residue: | 332 |
Sequence: | MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVS
GILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGAN
MKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL
IYALRSQELRKTFKEIICCYPLGGLCDLSSRY
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BDBM50214689 |
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n/a |
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Name | BDBM50214689 |
Synonyms: | 1-{4-[(1S)-2-(1-amino-3-methylbutyl)-4-trifluoromethylphenyl]-4-[(2R)-aminoacetamido-3-(2,4-dichlorophenyl)propionyl]}-piperazine | CHEMBL236424 |
Type | Small organic molecule |
Emp. Form. | C27H34Cl2F3N5O2 |
Mol. Mass. | 588.492 |
SMILES | CC(C)C[C@H](N)c1cc(ccc1N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1Cl)NC(=O)CN)C(F)(F)F |
Structure |
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