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TargetMelanocortin receptor 4
LigandBDBM50214689
Substrate/Competitorn/a
Meas. Tech.ChEMBL_448087
Ki 1.8±n/a nM
Citation Tran JATucci FCJiang WMarinkovic DChen CWArellano MMarkison SFleck BAWen JWhite NSPontillo JSaunders JMarks DHoare SRMadan AFoster ACChen C Pyrrolidinones as orally bioavailable antagonists of the human melanocortin-4 receptor with anti-cachectic activity. Bioorg Med Chem 15:5166-76 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Melanocortin receptor 4
Name:Melanocortin receptor 4
Synonyms:MC4-R | MC4R | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R)
Type:Enzyme
Mol. Mass.:36949.50
Organism:Homo sapiens (Human)
Description:P32245
Residue:332
Sequence:
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVS
GILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGAN
MKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL
IYALRSQELRKTFKEIICCYPLGGLCDLSSRY
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50214689
n/a
NameBDBM50214689
Synonyms:1-{4-[(1S)-2-(1-amino-3-methylbutyl)-4-trifluoromethylphenyl]-4-[(2R)-aminoacetamido-3-(2,4-dichlorophenyl)propionyl]}-piperazine | CHEMBL236424
TypeSmall organic molecule
Emp. Form.C27H34Cl2F3N5O2
Mol. Mass.588.492
SMILESCC(C)C[C@H](N)c1cc(ccc1N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1Cl)NC(=O)CN)C(F)(F)F
Structure
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