Reaction Details |
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Target | Purine nucleoside phosphorylase |
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Ligand | BDBM50214708 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_447602 (CHEMBL896616) |
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IC50 | 9.5±n/a nM |
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Citation | Hikishima, S; Hashimoto, M; Magnowska, L; Bzowska, A; Yokomatsu, T Synthesis and biological evaluation of 9-deazaguanine derivatives connected by a linker to difluoromethylene phosphonic acid as multi-substrate analogue inhibitors of PNP. Bioorg Med Chem Lett17:4173-7 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Purine nucleoside phosphorylase |
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Name: | Purine nucleoside phosphorylase |
Synonyms: | Inosine phosphorylase | Inosine-guanosine phosphorylase | NP | PNP | PNPH_HUMAN | Purine nucleoside phosphorylase (PNPase) |
Type: | Enzyme |
Mol. Mass.: | 32119.53 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 289 |
Sequence: | MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRST
VPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGL
NPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQ
MGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSL
ITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS
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BDBM50214708 |
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n/a |
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Name | BDBM50214708 |
Synonyms: | 6-(2-amino-4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)-1,1-difluorohexylphosphonic acid | CHEMBL236711 |
Type | Small organic molecule |
Emp. Form. | C12H17F2N4O4P |
Mol. Mass. | 350.2583 |
SMILES | Nc1nc2c(CCCCCC(F)(F)P(O)(O)=O)c[nH]c2c(=O)[nH]1 |
Structure |
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