| Reaction Details |
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 | Report a problem with these data |
| Target | Gonadotropin-releasing hormone receptor |
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| Ligand | BDBM50215173 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_448200 (CHEMBL898460) |
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| Ki | 100±n/a nM |
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| Citation |  Lanier, MC; Feher, M; Ashweek, NJ; Loweth, CJ; Rueter, JK; Slee, DH; Williams, JP; Zhu, YF; Sullivan, SK; Brown, MS Selection, synthesis, and structure-activity relationship of tetrahydropyrido[4,3-d]pyrimidine-2,4-diones as human GnRH receptor antagonists. Bioorg Med Chem15:5590-603 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Gonadotropin-releasing hormone receptor |
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| Name: | Gonadotropin-releasing hormone receptor |
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| Synonyms: | GNRHR | GNRHR_HUMAN | GRHR | GnRH receptor | GnRH-R | Gonadotropin releasing hormone 1 (GnRHR1) | Gonadotropin-releasing hormone receptor | Gonadotropin-releasing hormone receptor (GnRH) |
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| Type: | Enzyme |
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| Mol. Mass.: | 37749.45 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P30968 |
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| Residue: | 328 |
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| Sequence: | MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKL
QKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYL
KLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRM
IHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTR
VLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRL
SDPVNHFFFLFAFLNPCFDPLIYGYFSL
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| BDBM50215173 |
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| n/a |
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| Name | BDBM50215173 |
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| Synonyms: | 1-(2,6-difluorobenzyl)-6-(4-methoxybenzyl)-3-(2-(methyl(2-(pyridin-2-yl)ethyl)amino)ethyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione | CHEMBL235051 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H35F2N5O3 |
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| Mol. Mass. | 575.6488 |
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| SMILES | COc1ccc(CN2CCc3c(C2)c(=O)n(CCN(C)CCc2ccccn2)c(=O)n3Cc2c(F)cccc2F)cc1 |
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| Structure | 
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