Reaction Details |
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Target | Gonadotropin-releasing hormone receptor |
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Ligand | BDBM50215175 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_448200 (CHEMBL898460) |
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Ki | 70±n/a nM |
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Citation | Lanier, MC; Feher, M; Ashweek, NJ; Loweth, CJ; Rueter, JK; Slee, DH; Williams, JP; Zhu, YF; Sullivan, SK; Brown, MS Selection, synthesis, and structure-activity relationship of tetrahydropyrido[4,3-d]pyrimidine-2,4-diones as human GnRH receptor antagonists. Bioorg Med Chem15:5590-603 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Gonadotropin-releasing hormone receptor |
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Name: | Gonadotropin-releasing hormone receptor |
Synonyms: | GNRHR | GNRHR_HUMAN | GRHR | GnRH receptor | GnRH-R | Gonadotropin releasing hormone 1 (GnRHR1) | Gonadotropin-releasing hormone receptor | Gonadotropin-releasing hormone receptor (GnRH) |
Type: | Enzyme |
Mol. Mass.: | 37749.45 |
Organism: | Homo sapiens (Human) |
Description: | P30968 |
Residue: | 328 |
Sequence: | MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKL
QKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYL
KLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRM
IHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTR
VLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRL
SDPVNHFFFLFAFLNPCFDPLIYGYFSL
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BDBM50215175 |
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n/a |
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Name | BDBM50215175 |
Synonyms: | (R)-1-(2,6-difluorobenzyl)-6-(4-chlorobenzyl)-3-(2-(dimethylamino)-2-phenylethyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione | CHEMBL430171 |
Type | Small organic molecule |
Emp. Form. | C31H31ClF2N4O2 |
Mol. Mass. | 565.053 |
SMILES | CN(C)[C@@H](Cn1c(=O)c2CN(Cc3ccc(Cl)cc3)CCc2n(Cc2c(F)cccc2F)c1=O)c1ccccc1 |
Structure |
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