Reaction Details |
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Target | Serine/threonine-protein kinase B-raf |
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Ligand | BDBM50215792 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_456550 (CHEMBL922916) |
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IC50 | 1240±n/a nM |
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Citation | Wickens, P; Kluender, H; Dixon, J; Brennan, C; Achebe, F; Bacchiocchi, A; Bankston, D; Bierer, D; Brands, M; Braun, D; Brown, MS; Chuang, CY; Dumas, J; Enyedy, I; Hofilena, G; Hong, Z; Housley, T; Jones, B; Khire, U; Kreiman, C; Kumarasinghe, E; Lowinger, T; Ott-Morgan, R; Perkins, L; Phillips, B; Schoenleber, R; Scott, WJ; Sheeler, R; Redman, A; Sun, X; Taylor, I; Wang, L; Wilhelm, S; Zhang, X; Zhang, M; Sullivan, E; Carter, C; Miglarese, M; Levy, J SAR of a novel 'Anthranilamide Like' series of VEGFR-2, multi protein kinase inhibitors for the treatment of cancer. Bioorg Med Chem Lett17:4378-81 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Serine/threonine-protein kinase B-raf |
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Name: | Serine/threonine-protein kinase B-raf |
Synonyms: | B-RAF | B-Raf Protein Kinase | B-Raf proto-oncogene serine/threonine-protein kinase | BRAF | BRAF1 | BRAF_HUMAN | RAFB1 | p94 | v-Raf murine sarcoma viral oncogene homolog B1 |
Type: | Serine/threonine-protein kinase |
Mol. Mass.: | 84446.00 |
Organism: | Homo sapiens (Human) |
Description: | P15056 |
Residue: | 766 |
Sequence: | MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEH
IEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTV
TSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDS
LKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRK
TFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPI
PQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQR
DRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSP
GPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDV
AVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHH
LHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATV
KSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNIN
NRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARS
LPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH
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BDBM50215792 |
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n/a |
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Name | BDBM50215792 |
Synonyms: | 4-((5-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)carbamoyl)thiazol-4-ylamino)methyl)-N-methylpicolinamide | CHEMBL247248 |
Type | Small organic molecule |
Emp. Form. | C19H15F2N5O4S |
Mol. Mass. | 447.415 |
SMILES | CNC(=O)c1cc(CNc2ncsc2C(=O)Nc2ccc3OC(F)(F)Oc3c2)ccn1 |
Structure |
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