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TargetMembrane-bound transcription factor site-1 protease
LigandBDBM50216184
Substrate/Competitorn/a
Meas. Tech.ChEMBL_447771 (CHEMBL896780)
IC50 9000±n/a nM
Citation Hay, BAAbrams, BZumbrunn, AYValentine, JJWarren, LCPetras, SFShelly, LDXia, AVarghese, AHHawkins, JLVan Camp, JARobbins, MDLandschulz, KHarwood, HJ Aminopyrrolidineamide inhibitors of site-1 protease. Bioorg Med Chem Lett17:4411-4 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Membrane-bound transcription factor site-1 protease
Name:Membrane-bound transcription factor site-1 protease
Synonyms:KIAA0091 | MBTP1_HUMAN | MBTPS1 | S1P | SKI1
Type:PROTEIN
Mol. Mass.:117773.36
Organism:Homo sapiens (Human)
Description:ChEMBL_641529
Residue:1052
Sequence:
MKLVNIWLLLLVVLLCGKKHLGDRLEKKSFEKAPCPGCSHLTLKVEFSSTVVEYEYIVAF
NGYFTAKARNSFISSALKSSEVDNWRIIPRNNPSSDYPSDFEVIQIKEKQKAGLLTLEDH
PNIKRVTPQRKVFRSLKYAESDPTVPCNETRWSQKWQSSRPLRRASLSLGSGFWHATGRH
SSRRLLRAIPRQVAQTLQADVLWQMGYTGANVRVAVFDTGLSEKHPHFKNVKERTNWTNE
RTLDDGLGHGTFVAGVIASMRECQGFAPDAELHIFRVFTNNQVSYTSWFLDAFNYAILKK
IDVLNLSIGGPDFMDHPFVDKVWELTANNVIMVSAIGNDGPLYGTLNNPADQMDVIGVGG
IDFEDNIARFSSRGMTTWELPGGYGRMKPDIVTYGAGVRGSGVKGGCRALSGTSVASPVV
AGAVTLLVSTVQKRELVNPASMKQALIASARRLPGVNMFEQGHGKLDLLRAYQILNSYKP
QASLSPSYIDLTECPYMWPYCSQPIYYGGMPTVVNVTILNGMGVTGRIVDKPDWQPYLPQ
NGDNIEVAFSYSSVLWPWSGYLAISISVTKKAASWEGIAQGHVMITVASPAETESKNGAE
QTSTVKLPIKVKIIPTPPRSKRVLWDQYHNLRYPPGYFPRDNLRMKNDPLDWNGDHIHTN
FRDMYQHLRSMGYFVEVLGAPFTCFDASQYGTLLMVDSEEEYFPEEIAKLRRDVDNGLSL
VIFSDWYNTSVMRKVKFYDENTRQWWMPDTGGANIPALNELLSVWNMGFSDGLYEGEFTL
ANHDMYYASGCSIAKFPEDGVVITQTFKDQGLEVLKQETAVVENVPILGLYQIPAEGGGR
IVLYGDSNCLDDSHRQKDCFWLLDALLQYTSYGVTPPSLSHSGNRQRPPSGAGSVTPERM
EGNHLHRYSKVLEAHLGDPKPRPLPACPRLSWAKPQPLNETAPSNLWKHQKLLSIDLDKV
VLPNFRSNRPQVRPLSPGESGAWDIPGGIMPGRYNQEVGQTIPVFAFLGAMVVLAFFVVQ
INKAKSRPKRRKPRVKRPQLMQQVHPPKTPSV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50216184
n/a
NameBDBM50216184
Synonyms:CHEMBL233165 | N-(2-fluorophenethyl)-4-isopropoxy-N-(pyrrolidin-3-yl)benzamide
TypeSmall organic molecule
Emp. Form.C22H27FN2O2
Mol. Mass.370.4604
SMILESCC(C)Oc1ccc(cc1)C(=O)N(CCc1ccccc1F)C1CCNC1 |w:22.23|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: