| Reaction Details |
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 | Report a problem with these data |
| Target | Membrane-bound transcription factor site-1 protease |
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| Ligand | BDBM50216192 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_447771 (CHEMBL896780) |
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| IC50 | >30000±n/a nM |
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| Citation |  Hay, BA; Abrams, B; Zumbrunn, AY; Valentine, JJ; Warren, LC; Petras, SF; Shelly, LD; Xia, A; Varghese, AH; Hawkins, JL; Van Camp, JA; Robbins, MD; Landschulz, K; Harwood, HJ Aminopyrrolidineamide inhibitors of site-1 protease. Bioorg Med Chem Lett17:4411-4 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Membrane-bound transcription factor site-1 protease |
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| Name: | Membrane-bound transcription factor site-1 protease |
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| Synonyms: | KIAA0091 | MBTP1_HUMAN | MBTPS1 | S1P | SKI1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 117773.36 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_641529 |
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| Residue: | 1052 |
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| Sequence: | MKLVNIWLLLLVVLLCGKKHLGDRLEKKSFEKAPCPGCSHLTLKVEFSSTVVEYEYIVAF
NGYFTAKARNSFISSALKSSEVDNWRIIPRNNPSSDYPSDFEVIQIKEKQKAGLLTLEDH
PNIKRVTPQRKVFRSLKYAESDPTVPCNETRWSQKWQSSRPLRRASLSLGSGFWHATGRH
SSRRLLRAIPRQVAQTLQADVLWQMGYTGANVRVAVFDTGLSEKHPHFKNVKERTNWTNE
RTLDDGLGHGTFVAGVIASMRECQGFAPDAELHIFRVFTNNQVSYTSWFLDAFNYAILKK
IDVLNLSIGGPDFMDHPFVDKVWELTANNVIMVSAIGNDGPLYGTLNNPADQMDVIGVGG
IDFEDNIARFSSRGMTTWELPGGYGRMKPDIVTYGAGVRGSGVKGGCRALSGTSVASPVV
AGAVTLLVSTVQKRELVNPASMKQALIASARRLPGVNMFEQGHGKLDLLRAYQILNSYKP
QASLSPSYIDLTECPYMWPYCSQPIYYGGMPTVVNVTILNGMGVTGRIVDKPDWQPYLPQ
NGDNIEVAFSYSSVLWPWSGYLAISISVTKKAASWEGIAQGHVMITVASPAETESKNGAE
QTSTVKLPIKVKIIPTPPRSKRVLWDQYHNLRYPPGYFPRDNLRMKNDPLDWNGDHIHTN
FRDMYQHLRSMGYFVEVLGAPFTCFDASQYGTLLMVDSEEEYFPEEIAKLRRDVDNGLSL
VIFSDWYNTSVMRKVKFYDENTRQWWMPDTGGANIPALNELLSVWNMGFSDGLYEGEFTL
ANHDMYYASGCSIAKFPEDGVVITQTFKDQGLEVLKQETAVVENVPILGLYQIPAEGGGR
IVLYGDSNCLDDSHRQKDCFWLLDALLQYTSYGVTPPSLSHSGNRQRPPSGAGSVTPERM
EGNHLHRYSKVLEAHLGDPKPRPLPACPRLSWAKPQPLNETAPSNLWKHQKLLSIDLDKV
VLPNFRSNRPQVRPLSPGESGAWDIPGGIMPGRYNQEVGQTIPVFAFLGAMVVLAFFVVQ
INKAKSRPKRRKPRVKRPQLMQQVHPPKTPSV
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| BDBM50216192 |
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| n/a |
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| Name | BDBM50216192 |
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| Synonyms: | CHEMBL233607 | N-(2-chlorophenethyl)-N-(azetidin-3-yl)-4-isopropoxybenzamide |
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| Type | Small organic molecule |
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| Emp. Form. | C21H25ClN2O2 |
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| Mol. Mass. | 372.888 |
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| SMILES | CC(C)Oc1ccc(cc1)C(=O)N(CCc1ccccc1Cl)C1CNC1 |
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| Structure | 
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