Reaction Details |
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Target | Membrane-bound transcription factor site-1 protease |
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Ligand | BDBM50216194 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_447771 (CHEMBL896780) |
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IC50 | 8±n/a nM |
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Citation | Hay, BA; Abrams, B; Zumbrunn, AY; Valentine, JJ; Warren, LC; Petras, SF; Shelly, LD; Xia, A; Varghese, AH; Hawkins, JL; Van Camp, JA; Robbins, MD; Landschulz, K; Harwood, HJ Aminopyrrolidineamide inhibitors of site-1 protease. Bioorg Med Chem Lett17:4411-4 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Membrane-bound transcription factor site-1 protease |
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Name: | Membrane-bound transcription factor site-1 protease |
Synonyms: | KIAA0091 | MBTP1_HUMAN | MBTPS1 | S1P | SKI1 |
Type: | PROTEIN |
Mol. Mass.: | 117773.36 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_641529 |
Residue: | 1052 |
Sequence: | MKLVNIWLLLLVVLLCGKKHLGDRLEKKSFEKAPCPGCSHLTLKVEFSSTVVEYEYIVAF
NGYFTAKARNSFISSALKSSEVDNWRIIPRNNPSSDYPSDFEVIQIKEKQKAGLLTLEDH
PNIKRVTPQRKVFRSLKYAESDPTVPCNETRWSQKWQSSRPLRRASLSLGSGFWHATGRH
SSRRLLRAIPRQVAQTLQADVLWQMGYTGANVRVAVFDTGLSEKHPHFKNVKERTNWTNE
RTLDDGLGHGTFVAGVIASMRECQGFAPDAELHIFRVFTNNQVSYTSWFLDAFNYAILKK
IDVLNLSIGGPDFMDHPFVDKVWELTANNVIMVSAIGNDGPLYGTLNNPADQMDVIGVGG
IDFEDNIARFSSRGMTTWELPGGYGRMKPDIVTYGAGVRGSGVKGGCRALSGTSVASPVV
AGAVTLLVSTVQKRELVNPASMKQALIASARRLPGVNMFEQGHGKLDLLRAYQILNSYKP
QASLSPSYIDLTECPYMWPYCSQPIYYGGMPTVVNVTILNGMGVTGRIVDKPDWQPYLPQ
NGDNIEVAFSYSSVLWPWSGYLAISISVTKKAASWEGIAQGHVMITVASPAETESKNGAE
QTSTVKLPIKVKIIPTPPRSKRVLWDQYHNLRYPPGYFPRDNLRMKNDPLDWNGDHIHTN
FRDMYQHLRSMGYFVEVLGAPFTCFDASQYGTLLMVDSEEEYFPEEIAKLRRDVDNGLSL
VIFSDWYNTSVMRKVKFYDENTRQWWMPDTGGANIPALNELLSVWNMGFSDGLYEGEFTL
ANHDMYYASGCSIAKFPEDGVVITQTFKDQGLEVLKQETAVVENVPILGLYQIPAEGGGR
IVLYGDSNCLDDSHRQKDCFWLLDALLQYTSYGVTPPSLSHSGNRQRPPSGAGSVTPERM
EGNHLHRYSKVLEAHLGDPKPRPLPACPRLSWAKPQPLNETAPSNLWKHQKLLSIDLDKV
VLPNFRSNRPQVRPLSPGESGAWDIPGGIMPGRYNQEVGQTIPVFAFLGAMVVLAFFVVQ
INKAKSRPKRRKPRVKRPQLMQQVHPPKTPSV
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BDBM50216194 |
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n/a |
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Name | BDBM50216194 |
Synonyms: | CHEMBL391935 | N-(2-chlorophenethyl)-N-(pyrrolidin-3-yl)-4-((3-o-tolylpiperidin-1-yl)methyl)benzamide |
Type | Small organic molecule |
Emp. Form. | C32H38ClN3O |
Mol. Mass. | 516.117 |
SMILES | Cc1ccccc1C1CCCN(Cc2ccc(cc2)C(=O)N(CCc2ccccc2Cl)C2CCNC2)C1 |w:31.33,7.7| |
Structure |
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