| Reaction Details |
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 | Report a problem with these data |
| Target | Hydroxycarboxylic acid receptor 2 |
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| Ligand | BDBM50132135 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_456679 (CHEMBL924060) |
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| EC50 | 2700±n/a nM |
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| Citation |  Gharbaoui, T; Skinner, PJ; Shin, YJ; Averbuj, C; Jung, JK; Johnson, BR; Duong, T; Decaire, M; Uy, J; Cherrier, MC; Webb, PJ; Tamura, SY; Zou, N; Rodriguez, N; Boatman, PD; Sage, CR; Lindstrom, A; Xu, J; Schrader, TO; Smith, BM; Chen, R; Richman, JG; Connolly, DT; Colletti, SL; Tata, JR; Semple, G Agonist lead identification for the high affinity niacin receptor GPR109a. Bioorg Med Chem Lett17:4914-9 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Hydroxycarboxylic acid receptor 2 |
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| Name: | Hydroxycarboxylic acid receptor 2 |
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| Synonyms: | G-protein coupled receptor 109A | G-protein coupled receptor HM74A | GPR109A | HCA2 | HCAR2 | HCAR2_HUMAN | HM74A | Hydroxycarboxylic acid receptor 2 | NIACR1 | Niacin Receptor GPR109A | Nicotinic acid receptor 1 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 41868.22 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Membranes from CHO cells expressing the recombinant human GPR109A were used in competition binding assay. |
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| Residue: | 363 |
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| Sequence: | MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWK
SSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTV
VAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSF
SICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVF
VICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPS
FPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGP
TSP
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| BDBM50132135 |
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| n/a |
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| Name | BDBM50132135 |
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| Synonyms: | 4,6-Dihydro-1H-furo[3,4-c]pyrazole-3-carboxylic acid | 4,6-dihydro-2H-furo[3,4-c]pyrazole-3-carboxylic acid | CHEMBL338071 |
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| Type | Small organic molecule |
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| Emp. Form. | C6H6N2O3 |
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| Mol. Mass. | 154.1234 |
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| SMILES | OC(=O)c1[nH]nc2COCc12 |
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| Structure | 
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