Ki Summary new BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetHydroxycarboxylic acid receptor 2
LigandBDBM50211363
Substrate/Competitorn/a
Meas. Tech.ChEMBL_456679
EC50 8300±n/a nM
Citation Gharbaoui TSkinner PJShin YJAverbuj CJung JKJohnson BRDuong TDecaire MUy JCherrier MCWebb PJTamura SYZou NRodriguez NBoatman PDSage CRLindstrom AXu JSchrader TOSmith BMChen RRichman JGConnolly DTColletti SLTata JRSemple G Agonist lead identification for the high affinity niacin receptor GPR109a. Bioorg Med Chem Lett 17:4914-9 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Hydroxycarboxylic acid receptor 2
Name:Hydroxycarboxylic acid receptor 2
Synonyms:G-protein coupled receptor 109A | G-protein coupled receptor HM74A | Hydroxycarboxylic acid receptor 2 | Niacin Receptor GPR109A | Nicotinic acid receptor 1
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:41868.22
Organism:Homo sapiens (Human)
Description:Membranes from CHO cells expressing the recombinant human GPR109A were used in competition binding assay.
Residue:363
Sequence:
MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWK
SSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTV
VAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSF
SICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVF
VICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPS
FPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGP
TSP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50211363
n/a
NameBDBM50211363
Synonyms:3-isopropyl-1H-pyrazole-5-carboxylic acid | 5-Isopropyl-1H-pyrazole-3-carboxylic acid | 5-isopropyl-3-carboxyl-pyrazole | CHEMBL238002
TypeSmall organic molecule
Emp. Form.C7H10N2O2
Mol. Mass.154.1665
SMILESCC(C)c1cc(n[nH]1)C(O)=O
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: