| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Hydroxycarboxylic acid receptor 2 |
|---|
| Ligand | BDBM50216550 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_456679 (CHEMBL924060) |
|---|
| EC50 | 6200±n/a nM |
|---|
| Citation |  Gharbaoui, T; Skinner, PJ; Shin, YJ; Averbuj, C; Jung, JK; Johnson, BR; Duong, T; Decaire, M; Uy, J; Cherrier, MC; Webb, PJ; Tamura, SY; Zou, N; Rodriguez, N; Boatman, PD; Sage, CR; Lindstrom, A; Xu, J; Schrader, TO; Smith, BM; Chen, R; Richman, JG; Connolly, DT; Colletti, SL; Tata, JR; Semple, G Agonist lead identification for the high affinity niacin receptor GPR109a. Bioorg Med Chem Lett17:4914-9 (2007) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Hydroxycarboxylic acid receptor 2 |
|---|
| Name: | Hydroxycarboxylic acid receptor 2 |
|---|
| Synonyms: | G-protein coupled receptor 109A | G-protein coupled receptor HM74A | GPR109A | HCA2 | HCAR2 | HCAR2_HUMAN | HM74A | Hydroxycarboxylic acid receptor 2 | NIACR1 | Niacin Receptor GPR109A | Nicotinic acid receptor 1 |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 41868.22 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Membranes from CHO cells expressing the recombinant human GPR109A were used in competition binding assay. |
|---|
| Residue: | 363 |
|---|
| Sequence: | MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWK
SSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTV
VAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSF
SICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVF
VICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPS
FPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGP
TSP
|
|
|
|---|
| BDBM50216550 |
|---|
| n/a |
|---|
| Name | BDBM50216550 |
|---|
| Synonyms: | 3-(3-chlorobenzyl)-1H-pyrazole-5-carboxylic acid | 5-(3-Chloro-benzyl)-1H-pyrazole-3-carboxylic acid | 5-meta-chlorobenzyl-3-carboxyl-pyrazole | CHEMBL394441 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C11H9ClN2O2 |
|---|
| Mol. Mass. | 236.654 |
|---|
| SMILES | OC(=O)c1cc(Cc2cccc(Cl)c2)[nH]n1 |
|---|
| Structure | 
|
|---|
Search and Browse
