| Reaction Details |
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 | Report a problem with these data |
| Target | Bone morphogenetic protein 1 |
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| Ligand | BDBM50216847 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_440136 (CHEMBL890447) |
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| IC50 | 17±n/a nM |
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| Citation |  Fish, PV; Allan, GA; Bailey, S; Blagg, J; Butt, R; Collis, MG; Greiling, D; James, K; Kendall, J; McElroy, A; McCleverty, D; Reed, C; Webster, R; Whitlock, GA Potent and selective nonpeptidic inhibitors of procollagen C-proteinase. J Med Chem50:3442-56 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Bone morphogenetic protein 1 |
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| Name: | Bone morphogenetic protein 1 |
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| Synonyms: | BMP-1 | BMP1 | BMP1_HUMAN | Mammalian tolloid protein | PCOLC | PCP | Procollagen C-proteinase | mTld |
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| Type: | PROTEIN |
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| Mol. Mass.: | 111254.03 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_518962 |
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| Residue: | 986 |
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| Sequence: | MPGVARLPLLLGLLLLPRPGRPLDLADYTYDLAEEDDSEPLNYKDPCKAAAFLGDIALDE
EDLRAFQVQQAVDLRRHTARKSSIKAAVPGNTSTPSCQSTNGQPQRGACGRWRGRSRSRR
AATSRPERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDEDSYIVFTY
RPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVREN
IQPGQEYNFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIG
QRTRLSKGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKI
ILNFTSLDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSS
NWVGKGFFAVYEAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSF
EIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGF
AVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNG
SITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSK
LHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQQDCVN
TFGSYECQCRSGFVLHDNKHDCKEAGCDHKVTSTSGTITSPNWPDKYPSKKECTWAISST
PGHRVKLTFMEMDIESQPECAYDHLEVFDGRDAKAPVLGRFCGSKKPEPVLATGSRMFLR
FYSDNSVQRKGFQASHATECGGQVRADVKTKDLYSHAQFGDNNYPGGVDCEWVIVAEEGY
GVELVFQTFEVEEETDCGYDYMELFDGYDSTAPRLGRYCGSGPPEEVYSAGDSVLVKFHS
DDTITKKGFHLRYTSTKFQDTLHSRK
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| BDBM50216847 |
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| n/a |
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| Name | BDBM50216847 |
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| Synonyms: | 2-(5-{(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl}-1,2,4-oxadiazol-3-yl)-N,N-dimethylisonicotinamide | CHEMBL447539 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H31N5O4 |
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| Mol. Mass. | 429.5126 |
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| SMILES | CN(C)C(=O)c1ccnc(c1)-c1noc(n1)[C@H](CCCC1CCCCC1)CC(=O)NO |
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| Structure | 
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