Reaction Details | |||
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Target | 11-beta-hydroxysteroid dehydrogenase 1 | ||
Ligand | BDBM50216915 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_448530 (CHEMBL897679) | ||
Ki | 7±n/a nM | ||
Citation | Sutin, L; Andersson, S; Bergquist, L; Castro, VM; Danielsson, E; James, S; Henriksson, M; Johansson, L; Kaiser, C; Flyrén, K; Williams, M Oxazolones as potent inhibitors of 11beta-hydroxysteroid dehydrogenase type 1. Bioorg Med Chem Lett17:4837-40 (2007) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
11-beta-hydroxysteroid dehydrogenase 1 | |||
Name: | 11-beta-hydroxysteroid dehydrogenase 1 | ||
Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1 | ||
Type: | Enzyme | ||
Mol. Mass.: | 32409.16 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P28845 | ||
Residue: | 292 | ||
Sequence: |
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BDBM50216915 | |||
n/a | |||
Name | BDBM50216915 | ||
Synonyms: | 2-(2-adamantylamino)-5-methyl-5-(trifluoromethyl)-1,3-oxazol-4(5H)-one | CHEMBL237798 | ||
Type | Small organic molecule | ||
Emp. Form. | C15H19F3N2O2 | ||
Mol. Mass. | 316.3188 | ||
SMILES | CC1(OC(NC2C3CC4CC(C3)CC2C4)=NC1=O)C(F)(F)F |c:17,TLB:11:10:14:7.6.5,11:6:9.10.12:14,THB:4:5:9.10.12:14,5:6:9:12.13.14,5:13:9:7.11.6,(17.02,-20.6,;15.48,-20.47,;13.96,-20.25,;13.74,-18.78,;12.4,-18.01,;11.14,-18.89,;11.13,-20.41,;9.72,-20.76,;8.39,-20.27,;7.2,-21.55,;8.7,-21.13,;10.11,-21.7,;8.69,-19.54,;9.74,-18.3,;8.39,-18.78,;15.08,-18,;16.18,-19.1,;17.7,-18.84,;15.1,-21.96,;14.71,-23.46,;16.59,-22.35,;13.6,-21.58,)| | ||
Structure |