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TargetMelanin-concentrating hormone receptor 1
LigandBDBM50217070
Substrate/Competitorn/a
Meas. Tech.ChEMBL_448548 (CHEMBL897698)
Ki 6.1±n/a nM
Citation Su, JTang, HMcKittrick, BAGu, HGuo, TQian, GBurnett, DAClader, JWGreenlee, WJHawes, BEO'neill, KSpar, BWeig, BKowalski, TSorota, S Synthesis of novel bicyclo[4.1.0]heptane and bicyclo[3.1.0]hexane derivatives as melanin-concentrating hormone receptor R1 antagonists. Bioorg Med Chem Lett17:4845-50 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Melanin-concentrating hormone receptor 1
Name:Melanin-concentrating hormone receptor 1
Synonyms:G-protein coupled receptor 24 | GPR24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCHR | MCHR-1 | MCHR1 | MCHR1_HUMAN | Melanin Concentrating Hormone 1 | Melanin-Concentrating Hormone Receptor 1 (MCH1R) | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 (MCH-1) | Melanin-concentrating hormone receptor 1 (MCH1) | Melanin-concentrating hormone receptor 1 (MCHR-1) | Melanin-concentrating hormone receptor 1 (MCHR1) | SLC-1 | SLC1 | Somatostatin receptor-like protein
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:45976.27
Organism:Homo sapiens (Human)
Description:Membranes from CHO-K1 cells stably expressing human MCH1R were used in assays.
Residue:422
Sequence:
MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARL
WEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTIC
LLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHF
GETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALS
FISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRI
LQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVY
LYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESK
GT
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50217070
n/a
NameBDBM50217070
Synonyms:1-((1S,2S,5S)-5-(2-(aminomethyl)thiazol-5-yl)bicyclo[3.1.0]hexan-2-yl)-3-(2,6-dichloropyridin-4-yl)-1-(3-((2S,5R)-2,5-dimethylpiperazin-1-yl)propyl)urea | CHEMBL237959
TypeSmall organic molecule
Emp. Form.C25H35Cl2N7OS
Mol. Mass.552.563
SMILESC[C@@H]1CN(CCCN([C@H]2CC[C@@]3(C[C@H]23)c2cnc(CN)s2)C(=O)Nc2cc(Cl)nc(Cl)c2)[C@@H](C)CN1
Structure
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