| Reaction Details |
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 | Report a problem with these data |
| Target | Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1 |
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| Ligand | BDBM50217482 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_448634 (CHEMBL897784) |
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| IC50 | 2118±n/a nM |
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| Citation |  Shaw, AW; Paone, DV; Nguyen, DN; Stump, CA; Burgey, CS; Mosser, SD; Salvatore, CA; Rutledge, RZ; Kane, SA; Koblan, KS; Graham, SL; Vacca, JP; Williams, TM Caprolactams as potent CGRP receptor antagonists for the treatment of migraine. Bioorg Med Chem Lett17:4795-8 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1 |
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| Name: | Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1 |
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| Synonyms: | Calcitonin-gene-related peptide receptor, CALCRL/RAMP1 |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of EBI is 327200 |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Calcitonin gene-related peptide type 1 receptor |
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| Synonyms: | Adrenomedullin receptor AM1; CALCRL/RAMP2 | CALCRL | CALRL_HUMAN | CGRP type 1 receptor | CGRP type 1 receptor mRNA | CGRPR | Calcitonin gene-related peptide (CGRP) receptor | Calcitonin gene-related peptide 1 (CGRP) | Calcitonin receptor-like receptor | Calcitonin receptor-like receptor (CLR) | Human CL receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 52980.45 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q16602 |
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| Residue: | 461 |
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| Sequence: | MEKKCTLYFLVLLPFFMILVTAELEESPEDSIQLGVTRNKIMTAQYECYQKIMQDPIQQA
EGVYCNRTWDGWLCWNDVAAGTESMQLCPDYFQDFDPSEKVTKICDQDGNWFRHPASNRT
WTNYTQCNVNTHEKVKTALNLFYLTIIGHGLSIASLLISLGIFFYFKSLSCQRITLHKNL
FFSFVCNSVVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGIYLHTL
IVVAVFAEKQHLMWYYFLGWGFPLIPACIHAIARSLYYNDNCWISSDTHLLYIIHGPICA
ALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLGIEFVLIPWRPEGKI
AEEVYDYIMHILMHFQGLLVSTIFCFFNGEVQAILRRNWNQYKIQFGNSFSNSEALRSAS
YTVSTISDGPGYSHDCPSEHLNGKSIHDIENVLLKPENLYN
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| Component 2 |
| Name: | Receptor activity-modifying protein 1 |
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| Synonyms: | Calcitonin-gene-related peptide receptor, CALCRL/RAMP1 | RAMP1 | RAMP1_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 16992.80 |
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| Organism: | Homo sapiens (Human) |
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| Description: | EBI_100673 |
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| Residue: | 148 |
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| Sequence: | MARALCRLPRRGLWLLLAHHLFMTTACQEANYGALLRELCLTQFQVDMEAVGETLWCDWG
RTIRSYRELADCTWHMAEKLGCFWPNAEVDRFFLAVHGRYFRSCPISGRAVRDPPGSILY
PFIVVPITVTLLVTALVVWQSKRTEGIV
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| BDBM50217482 |
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| n/a |
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| Name | BDBM50217482 |
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| Synonyms: | CHEMBL236516 | tert-butyl 2-((3S,7S)-2-oxo-3-(4-(2-oxo-1,2-dihydroquinazolin-3(4H)-yl)piperidine-1-carboxamido)-7-phenylazepan-1-yl)acetate |
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| Type | Small organic molecule |
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| Emp. Form. | C32H41N5O5 |
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| Mol. Mass. | 575.6984 |
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| SMILES | CC(C)(C)OC(=O)CN1[C@@H](CCC[C@H](NC(=O)N2CCC(CC2)N2Cc3ccccc3NC2=O)C1=O)c1ccccc1 |
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| Structure | 
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