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TargetThymidine kinase
LigandBDBM50217798
Substrate/Competitorn/a
Meas. Tech.ChEMBL_444706
IC50 2900±n/a nM
Citation Robins MJNowak IRajwanshi VKMiranda KCannon JFPeterson MAAndrei GSnoeck RDe Clercq EBalzarini J Synthesis and antiviral evaluation of 6-(alkyl-heteroaryl)furo[2,3-d]pyrimidin-2(3H)-one nucleosides and analogues with ethynyl, ethenyl, and ethyl spacers at C6 of the furopyrimidine core. J Med Chem 50:3897-905 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Thymidine kinase
Name:Thymidine kinase
Synonyms:n/a
Type:PROTEIN
Mol. Mass.:37819.99
Organism:Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3)
Description:ChEMBL_444706
Residue:341
Sequence:
MSTDKTDVKMGVLRIYLDGAYGIGKTTAAEEFLHHFAITPNRILLIGEPLSYWRNLAGED
AICGIYGTQTRRLNGDVSPEDAQRLTAHFQSLFCSPHAIMHAKISALMDTSTSDLVQVNK
EPYKIMLSDRHPIASTICFPLSRYLVGDMSPAALPGLLFTLPAEPPGTNLVVCTVSLPSH
LSRVSKRARPGETVNLPFVMVLRNVYIMLINTIIFLKTNNWHAGWNTLSFCNDVFKQKLQ
KSECIKLREVPGIEDTLFAVLKLPELCGEFGNILPLWAWGMETLSNCSRSMSPFVLSLEQ
TPQHAAQELKTLLPQMTPANMSSGAWNILKELVNAVQDNTS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50217798
n/a
NameBDBM50217798
Synonyms:3-(2-deoxy-beta-D-erythro-pentofuranosyl)-6-[2-(pent-1-yn-1-yl)-pyrid-5-yl]furo[2,3-d]pyrimidin-2(3H)-one | CHEMBL397671
TypeSmall organic molecule
Emp. Form.C21H21N3O5
Mol. Mass.395.4085
SMILESCCCC#Cc1ccc(cn1)-c1cc2cn([C@H]3C[C@H](O)[C@@H](CO)O3)c(=O)nc2o1
Structure
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