| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-1 adrenergic receptor |
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| Ligand | BDBM50218166 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_457030 (CHEMBL924394) |
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| Ki | 200±n/a nM |
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| Citation |  Lafontaine, JA; Day, RF; Dibrino, J; Hadcock, JR; Hargrove, DM; Linhares, M; Martin, KA; Maurer, TS; Nardone, NA; Tess, DA; Dasilva-Jardine, P Discovery of potent and orally bioavailable heterocycle-based beta3-adrenergic receptor agonists, potential therapeutics for the treatment of obesity. Bioorg Med Chem Lett17:5245-50 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-1 adrenergic receptor |
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| Name: | Beta-1 adrenergic receptor |
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| Synonyms: | ADRB1 | ADRB1R | ADRB1_HUMAN | B1AR | Beta-1 adrenoceptor | adrenergic Beta1 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 51338.40 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08588 |
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| Residue: | 477 |
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| Sequence: | MGAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAG
MGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVV
WGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVC
TVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIM
AFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAP
LANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFV
FFNWLGYANSAFNPIIYCRSPDFRKAFQRLLCCARRAARRRHATHGDRPRASGCLARPGP
PPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPGFASESKV
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| BDBM50218166 |
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| n/a |
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| Name | BDBM50218166 |
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| Synonyms: | (R)-2-(2-(4-(oxazol-4-yl)phenoxy)ethylamino)-1-(pyridin-3-yl)ethanol | CHEMBL249336 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H19N3O3 |
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| Mol. Mass. | 325.3618 |
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| SMILES | O[C@@H](CNCCOc1ccc(cc1)-c1cocn1)c1cccnc1 |
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| Structure | 
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