Reaction Details |
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Target | Retinoic acid receptor RXR-alpha |
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Ligand | BDBM50218484 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_448792 (CHEMBL897938) |
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IC50 | 2900±n/a nM |
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Citation | Sakaki, J; Konishi, K; Kishida, M; Gunji, H; Kanazawa, T; Uchiyama, H; Fukaya, H; Mitani, H; Kimura, M Synthesis and structure-activity relationship of RXR antagonists based on the diazepinylbenzoic acid structure. Bioorg Med Chem Lett17:4808-11 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Retinoic acid receptor RXR-alpha |
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Name: | Retinoic acid receptor RXR-alpha |
Synonyms: | NR2B1 | Nuclear receptor subfamily 2 group B member 1 | Nuclear receptor subfamily 4 group A member 2 | Nuclear receptor subfamily 4 group A member 2/Retinoic acid receptor RXR-alpha | RXRA | RXRA_HUMAN | Retinoic acid receptor RXR-alpha/gamma | Retinoid X receptor alpha | Retinoid receptor |
Type: | PROTEIN |
Mol. Mass.: | 50820.38 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1456363 |
Residue: | 462 |
Sequence: | MDTKHFLPLDFSTQVNSSLTSPTGRGSMAAPSLHPSLGPGIGSPGQLHSPISTLSSPING
MGPPFSVISSPMGPHSMSVPTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVP
AHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLID
KRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAEL
AVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVIL
LRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDM
QMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLL
RLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQMT
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BDBM50218484 |
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n/a |
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Name | BDBM50218484 |
Synonyms: | 4-{2-[(adamantane-1-carbonyl)-amino]-5,7,7,10,10-pentamethyl-7,8,9,10-tetrahydro-5H-5,13-diaza-benzo[4,5]cyclohepta[1,2-b]naphthalen-12-yl}-benzoic acid | CHEMBL394721 |
Type | Small organic molecule |
Emp. Form. | C40H45N3O3 |
Mol. Mass. | 615.8036 |
SMILES | CN1c2ccc(NC(=O)C34CC5CC(CC(C5)C3)C4)cc2N=C(c2ccc(cc2)C(O)=O)c2cc3c(cc12)C(C)(C)CCC3(C)C |t:25,TLB:18:9:16:12.13.14,7:9:16:12.13.14,THB:18:13:10.9.17:16,14:13:10:17.15.16,14:15:10:12.18.13| |
Structure |
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