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TargetSerine/threonine-protein kinase Chk1
LigandBDBM50218716
Substrate/Competitorn/a
Meas. Tech.ChEMBL_444965 (CHEMBL894121)
IC50 3600±n/a nM
Citation Wang, LSullivan, GMHexamer, LAHasvold, LAThalji, RPrzytulinska, MTao, ZFLi, GChen, ZXiao, ZGu, WZXue, JBui, MHMerta, PKovar, PBouska, JJZhang, HPark, CStewart, KDSham, HLSowin, TJRosenberg, SHLin, NH Design, synthesis, and biological activity of 5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-one-based potent and selective Chk-1 inhibitors. J Med Chem50:4162-76 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Serine/threonine-protein kinase Chk1
Name:Serine/threonine-protein kinase Chk1
Synonyms:CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1)
Type:Enzyme Catalytic Domain
Mol. Mass.:54443.02
Organism:Homo sapiens (Human)
Description:gi_166295192
Residue:476
Sequence:
MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINK
MLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVY
LHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK
RREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLA
LLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDF
SPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLL
GTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRR
NNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50218716
n/a
NameBDBM50218716
Synonyms:3-(2-methoxy-phenyl)-5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-one | CHEMBL395037
TypeSmall organic molecule
Emp. Form.C20H16N2O2
Mol. Mass.316.3532
SMILESCOc1ccccc1-c1ccc2c(Nc3ccccc3NC2=O)c1
Structure
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