| Reaction Details |
|---|
 | Report a problem with these data |
| Target | cAMP-dependent protein kinase catalytic subunit alpha/beta/gamma |
|---|
| Ligand | BDBM50218709 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_445007 (CHEMBL894162) |
|---|
| IC50 | >10000±n/a nM |
|---|
| Citation |  Wang, L; Sullivan, GM; Hexamer, LA; Hasvold, LA; Thalji, R; Przytulinska, M; Tao, ZF; Li, G; Chen, Z; Xiao, Z; Gu, WZ; Xue, J; Bui, MH; Merta, P; Kovar, P; Bouska, JJ; Zhang, H; Park, C; Stewart, KD; Sham, HL; Sowin, TJ; Rosenberg, SH; Lin, NH Design, synthesis, and biological activity of 5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-one-based potent and selective Chk-1 inhibitors. J Med Chem50:4162-76 (2007) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| cAMP-dependent protein kinase catalytic subunit alpha/beta/gamma |
|---|
| Name: | cAMP-dependent protein kinase catalytic subunit alpha/beta/gamma |
|---|
| Synonyms: | cAMP-dependent protein kinase (PKA) |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | ASSAY_ID of ChEMBL is 217489 |
|---|
| Components: | This complex has 3 components. |
|---|
| Component 1 |
| Name: | cAMP-dependent protein kinase catalytic subunit beta |
|---|
| Synonyms: | KAPCB_HUMAN | PKA C-beta | PKAC-beta | PRKACB | cAMP-dependent protein kinase (PKA) | cAMP-dependent protein kinase beta-1 catalytic subunit | cAMP-dependent protein kinase catalytic subunit beta |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 40631.25 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_586348 |
|---|
| Residue: | 351 |
|---|
| Sequence: | MGNAATAKKGSEVESVKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVML
VKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMV
MEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGY
IQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF
ADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFAT
TDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEEDIRVSITEKCAKEFGEF
|
|
|
|---|
| Component 2 |
| Name: | cAMP-dependent protein kinase catalytic subunit alpha |
|---|
| Synonyms: | KAPCA_HUMAN | PKA C-alpha | PKACA | PRKACA | cAMP-dependent protein kinase (PKA) | cAMP-dependent protein kinase catalytic (PKA) | cAMP-dependent protein kinase catalytic subunit alpha | cAMP-dependent protein kinase catalytic subunit alpha (PKA) | cAMP-dependent protein kinase catalytic subunit alpha (PKACA) | cAMP-dependent protein kinase catalytic subunit alpha (PKAc) | cAMP-dependent protein kinase catalytic subunit alpha isoform 1 | cAMP-dependent protein kinase, alpha-catalytic subunit |
|---|
| Type: | Enzyme Catalytic Subunit |
|---|
| Mol. Mass.: | 40598.73 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 351 |
|---|
| Sequence: | MGNAAAAKKGSEQESVKEFLAKAKEDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVML
VKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMV
MEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGY
IQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF
ADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFAT
TDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF
|
|
|
|---|
| Component 3 |
| Name: | cAMP-dependent protein kinase catalytic subunit gamma |
|---|
| Synonyms: | KAPCG_HUMAN | PKA C-gamma | PRKACG | cAMP-dependent protein kinase (PKA) | cAMP-dependent protein kinase catalytic subunit gamma |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 40442.03 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_104720 |
|---|
| Residue: | 351 |
|---|
| Sequence: | MGNAPAKKDTEQEESVNEFLAKARGDFLYRWGNPAQNTASSDQFERLRTLGMGSFGRVML
VRHQETGGHYAMKILNKQKVVKMKQVEHILNEKRILQAIDFPFLVKLQFSFKDNSYLYLV
MEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVLAVQYLHSLDLIHRDLKPENLLIDQQGY
LQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAVGFPPFY
ADQPIQIYEKIVSGRVRFPSKLSSDLKHLLRSLLQVDLTKRFGNLRNGVGDIKNHKWFAT
TSWIAIYEKKVEAPFIPKYTGPGDASNFDDYEEEELRISINEKCAKEFSEF
|
|
|
|---|
| BDBM50218709 |
|---|
| n/a |
|---|
| Name | BDBM50218709 |
|---|
| Synonyms: | 2-[3-(3-methoxy-4-nitrophenyl)-11-oxo-10,11-dihydro-5Hdibenzo[b,e][1,4]diazepin-8-yl]-2-methyl-N-(4-morpholin-4-ylphenyl)propanamide | CHEMBL389745 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C34H35N5O4 |
|---|
| Mol. Mass. | 577.6728 |
|---|
| SMILES | COc1cc(ccc1N)-c1ccc2c(Nc3ccc(cc3NC2=O)C(C)(C)C(=O)Nc2ccc(cc2)N2CCOCC2)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
