| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase MARK2 |
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| Ligand | BDBM50218700 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_444998 (CHEMBL894156) |
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| IC50 | 13860±n/a nM |
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| Citation |  Wang, L; Sullivan, GM; Hexamer, LA; Hasvold, LA; Thalji, R; Przytulinska, M; Tao, ZF; Li, G; Chen, Z; Xiao, Z; Gu, WZ; Xue, J; Bui, MH; Merta, P; Kovar, P; Bouska, JJ; Zhang, H; Park, C; Stewart, KD; Sham, HL; Sowin, TJ; Rosenberg, SH; Lin, NH Design, synthesis, and biological activity of 5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-one-based potent and selective Chk-1 inhibitors. J Med Chem50:4162-76 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase MARK2 |
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| Name: | Serine/threonine-protein kinase MARK2 |
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| Synonyms: | ELKL motif kinase 1 | EMK1 | MAP/microtubule affinity-regulating kinase 2 | MARK2 | MARK2_HUMAN | PAR1 homolog | Par-1 | Serine/threonine-protein kinase MARK2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 87953.09 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_774586 |
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| Residue: | 788 |
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| Sequence: | MSSARTPLPTLNERDTEQPTLGHLDSKPSSKSNMIRGRNSATSADEQPHIGNYRLLKTIG
KGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIE
TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAEN
LLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVIL
YTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMK
DRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLL
LGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAAGPAIPTS
NSYSKKTQSNNAENKRPEEDRESGRKASSTAKVPASPLPGLERKKTTPTPSTNSVLSTST
NRSRNSPLLERASLGQASIQNGKDSLTMPGSRASTASASAAVSAARPRQHQKSMSASVHP
NKASGLPPTESNCEVPRPSTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAG
QLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLSFRFARRNLNEPE
SKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDA
NSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIAS
KIANELKL
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| BDBM50218700 |
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| n/a |
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| Name | BDBM50218700 |
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| Synonyms: | 2-[3-(3-methoxy-4-nitrophenyl)-11-oxo-10,11-dihydro-5Hdibenzo[b,e][1,4]diazepin-8-yl]-N-[4-(4-morpholinyl)phenyl]acetamide | CHEMBL395080 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H31N5O4 |
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| Mol. Mass. | 549.6196 |
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| SMILES | COc1cc(ccc1N)-c1ccc2c(Nc3ccc(CC(=O)Nc4ccc(cc4)N4CCOCC4)cc3NC2=O)c1 |
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| Structure | 
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