Reaction Details |
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Target | Protein kinase C delta type |
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Ligand | BDBM50218700 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_445008 (CHEMBL894163) |
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IC50 | >50000±n/a nM |
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Citation | Wang, L; Sullivan, GM; Hexamer, LA; Hasvold, LA; Thalji, R; Przytulinska, M; Tao, ZF; Li, G; Chen, Z; Xiao, Z; Gu, WZ; Xue, J; Bui, MH; Merta, P; Kovar, P; Bouska, JJ; Zhang, H; Park, C; Stewart, KD; Sham, HL; Sowin, TJ; Rosenberg, SH; Lin, NH Design, synthesis, and biological activity of 5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-one-based potent and selective Chk-1 inhibitors. J Med Chem50:4162-76 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Protein kinase C delta type |
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Name: | Protein kinase C delta type |
Synonyms: | KPCD_HUMAN | PKC delta | PKCD | PRKCD | Protein Kinase C- delta | Protein kinase C, PKC; classical/novel | nPKC-delta |
Type: | Enzyme |
Mol. Mass.: | 77516.79 |
Organism: | Homo sapiens (Human) |
Description: | The recombinant human PKC enzymes were
produced using a baculovirus expression system in SF9 cells |
Residue: | 676 |
Sequence: | MAPFLRIAFNSYELGSLQAEDEANQPFCAVKMKEALSTERGKTLVQKKPTMYPEWKSTFD
AHIYEGRVIQIVLMRAAEEPVSEVTVGVSVLAERCKKNNGKAEFWLDLQPQAKVLMSVQY
FLEDVDCKQSMRSEDEAKFPTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVW
GLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDTIFQKERFNIDMPHRFKVHNYMS
PTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEALNQVTQRASR
RSDSASSEPVGIYQGFEKKTGVAGEDMQDNSGTYGKIWEGSSKCNINNFIFHKVLGKGSF
GKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTK
DHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVL
LDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYE
MLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKRLGVTGNIKIH
PFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARLSYSDKNLIDSMDQSAF
AGFSFVNPKFEHLLED
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BDBM50218700 |
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n/a |
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Name | BDBM50218700 |
Synonyms: | 2-[3-(3-methoxy-4-nitrophenyl)-11-oxo-10,11-dihydro-5Hdibenzo[b,e][1,4]diazepin-8-yl]-N-[4-(4-morpholinyl)phenyl]acetamide | CHEMBL395080 |
Type | Small organic molecule |
Emp. Form. | C32H31N5O4 |
Mol. Mass. | 549.6196 |
SMILES | COc1cc(ccc1N)-c1ccc2c(Nc3ccc(CC(=O)Nc4ccc(cc4)N4CCOCC4)cc3NC2=O)c1 |
Structure |
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