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TargetSerine/threonine-protein kinase Chk1
LigandBDBM50218733
Substrate/Competitorn/a
Meas. Tech.ChEMBL_444966 (CHEMBL894122)
EC50>10000±n/a nM
Citation Wang, LSullivan, GMHexamer, LAHasvold, LAThalji, RPrzytulinska, MTao, ZFLi, GChen, ZXiao, ZGu, WZXue, JBui, MHMerta, PKovar, PBouska, JJZhang, HPark, CStewart, KDSham, HLSowin, TJRosenberg, SHLin, NH Design, synthesis, and biological activity of 5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-one-based potent and selective Chk-1 inhibitors. J Med Chem50:4162-76 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Serine/threonine-protein kinase Chk1
Name:Serine/threonine-protein kinase Chk1
Synonyms:CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1)
Type:Enzyme Catalytic Domain
Mol. Mass.:54443.02
Organism:Homo sapiens (Human)
Description:gi_166295192
Residue:476
Sequence:
MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINK
MLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVY
LHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK
RREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLA
LLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDF
SPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLL
GTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRR
NNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
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  Blast E-value cutoff:
BDBM50218733
n/a
NameBDBM50218733
Synonyms:3-[3-(3-methoxy-4-nitrophenyl)-11-oxo-10,11-dihydro-5Hdibenzo[b,e][1,4]diazepin-8-yl]-N,N-dimethylpropanamide | CHEMBL395775
TypeSmall organic molecule
Emp. Form.C25H26N4O3
Mol. Mass.430.4989
SMILESCOc1cc(ccc1N)-c1ccc2c(Nc3ccc(CCC(=O)N(C)C)cc3NC2=O)c1
Structure
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