Reaction Details | |||
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Target | Aurora kinase B | ||
Ligand | BDBM50191418 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_445190 (CHEMBL894338) | ||
IC50 | 8000±n/a nM | ||
Citation | Myrianthopoulos, V; Magiatis, P; Ferandin, Y; Skaltsounis, AL; Meijer, L; Mikros, E An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted indirubins. J Med Chem50:4027-37 (2007) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Aurora kinase B | |||
Name: | Aurora kinase B | ||
Synonyms: | AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B | ||
Type: | Protein | ||
Mol. Mass.: | 39327.72 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q96GD4 | ||
Residue: | 344 | ||
Sequence: |
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BDBM50191418 | |||
n/a | |||
Name | BDBM50191418 | ||
Synonyms: | (2'Z,3'E)-7-chloroindirubin-3'-oxime | CHEMBL213650 | ||
Type | Small organic molecule | ||
Emp. Form. | C16H10ClN3O2 | ||
Mol. Mass. | 311.723 | ||
SMILES | Oc1[nH]c2c(Cl)cccc2c1-c1[nH]c2ccccc2c1N=O |(1.25,-3.25,;1.71,-1.79,;3.17,-1.31,;3.18,.23,;4.31,1.25,;5.78,.77,;3.99,2.75,;2.53,3.23,;1.39,2.2,;1.71,.71,;.81,-.54,;-.75,-.54,;-1.65,-1.79,;-3.12,-1.32,;-4.45,-2.1,;-5.79,-1.33,;-5.79,.22,;-4.46,.99,;-3.12,.22,;-1.66,.7,;-1.17,2.18,;-2.26,3.27,)| | ||
Structure |