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TargetGPR24
LigandBDBM50219045
Substrate/Competitorn/a
Meas. Tech.ChEMBL_445301
Ki 27±n/a nM
Citation Chen CAJiang YLu KDaniewska IMazza CGNegron LForray CParola TLi BHegde LGWolinsky TDCraig DAKong RWetzel JMAndersen KMarzabadi MR Synthesis and SAR investigations for novel melanin-concentrating hormone 1 receptor (MCH1) antagonists part 2: A hybrid strategy combining key fragments of HTS hits. J Med Chem 50:3883-90 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
GPR24
Name:GPR24
Synonyms:Melanin Concentrating Hormone 1 | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1
Type:Enzyme Catalytic Domain
Mol. Mass.:39740.39
Organism:RAT
Description:Melanin Concentrating Hormone 1 GPR24 RAT::P97639
Residue:360
Sequence:
QATCTGCMDLQTSLLSTGPNASNISDGQDNLTLPGSPPRTGSVSYINIIMPSVFGTICLL
GIVGNSTVIFAVVKKSKLHWCSNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGE
TMCTLITAMDANSQFTSTYILTAMTIDRYLATVHPISSTKFRKPSMATLVICLLWALSFI
SITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVKILQ
RMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLY
NAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRTVSNAQTADEERTESKGT
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50219045
n/a
NameBDBM50219045
Synonyms:CHEMBL242003 | N-(5-{1-[4-(3,4-difluorophenoxy)benzyl]-4-piperidinyl}-4-methylphenyl)-2-methylpropanamide
TypeSmall organic molecule
Emp. Form.C29H32F2N2O2
Mol. Mass.478.5734
SMILESCC(C)C(=O)Nc1cc(ccc1C)C1CCN(Cc2ccc(Oc3ccc(F)c(F)c3)cc2)CC1
Structure
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