Reaction Details |
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Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4B |
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Ligand | BDBM50219269 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_457129 (CHEMBL940738) |
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IC50 | 2.2±n/a nM |
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Citation | Kuang, R; Shue, HJ; Blythin, DJ; Shih, NY; Gu, D; Chen, X; Schwerdt, J; Lin, L; Ting, PC; Zhu, X; Aslanian, R; Piwinski, JJ; Xiao, L; Prelusky, D; Wu, P; Zhang, J; Zhang, X; Celly, CS; Minnicozzi, M; Billah, M; Wang, P Discovery of a highly potent series of oxazole-based phosphodiesterase 4 inhibitors. Bioorg Med Chem Lett17:5150-4 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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cAMP-specific 3',5'-cyclic phosphodiesterase 4B |
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Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4B |
Synonyms: | 3',5'-cyclic phosphodiesterase | DPDE4 | Isoform PDE4B1 | PDE32 | PDE4B | PDE4B1 | PDE4B_HUMAN | Phosphodiesterase 4B | Phosphodiesterase 4B (PDE4B) | Phosphodiesterase 4B (PDE4B1) | Phosphodiesterase Type 4 (PDE4B) |
Type: | Protein |
Mol. Mass.: | 83318.87 |
Organism: | Homo sapiens (Human) |
Description: | Q07343 |
Residue: | 736 |
Sequence: | MKKSRSVMTVMADDNVKDYFECSLSKSYSSSSNTLGIDLWRGRRCCSGNLQLPPLSQRQS
ERARTPEGDGISRPTTLPLTTLPSIAITTVSQECFDVENGPSPGRSPLDPQASSSAGLVL
HATFPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVR
NNFTILTNLHGTSNKRSPAASQPPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTYR
SVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKK
KQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSH
NRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHV
LLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHL
AVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTS
SGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEI
SPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSP
SPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLG
ETDIDIATEDKSPVDT
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BDBM50219269 |
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n/a |
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Name | BDBM50219269 |
Synonyms: | (5-(aminomethyl)-2-(8-methoxy-2-(trifluoromethyl)quinolin-5-yl)oxazol-4-yl)(4-(4,6-dimethoxypyrimidin-2-yl)piperazin-1-yl)methanone | CHEMBL401345 |
Type | Small organic molecule |
Emp. Form. | C26H26F3N7O5 |
Mol. Mass. | 573.5237 |
SMILES | COc1cc(OC)nc(n1)N1CCN(CC1)C(=O)c1nc(oc1CN)-c1ccc(OC)c2nc(ccc12)C(F)(F)F |
Structure |
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