| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein phosphatase non-receptor type 2 |
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| Ligand | BDBM50219567 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_445833 (CHEMBL896127) |
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| Ki | 6±n/a nM |
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| Citation |  Wilson, DP; Wan, ZK; Xu, WX; Kirincich, SJ; Follows, BC; Joseph-McCarthy, D; Foreman, K; Moretto, A; Wu, J; Zhu, M; Binnun, E; Zhang, YL; Tam, M; Erbe, DV; Tobin, J; Xu, X; Leung, L; Shilling, A; Tam, SY; Mansour, TS; Lee, J Structure-based optimization of protein tyrosine phosphatase 1B inhibitors: from the active site to the second phosphotyrosine binding site. J Med Chem50:4681-98 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein phosphatase non-receptor type 2 |
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| Name: | Tyrosine-protein phosphatase non-receptor type 2 |
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| Synonyms: | PTN2_HUMAN | PTPN2 | PTPT | T-cell protein tyrosine phosphatase (TCPTP) | T-cell protein-tyrosine phosphatase | TC-PTP | TCPTP | Tyrosine-protein phosphatase non-receptor type 2 | Tyrosine-protein phosphatase non-receptor type 2 (TC-PTP) |
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| Type: | Protein |
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| Mol. Mass.: | 48481.80 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P17706 |
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| Residue: | 415 |
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| Sequence: | MPTTIEREFEELDTQRRWQPLYLEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVK
LQNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKES
VKCAQYWPTDDQEMLFKETGFSVKLLSEDVKSYYTVHLLQLENINSGETRTISHFHYTTW
PDFGVPESPASFLNFLFKVRESGSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGD
DINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCIKGDSSIQKRWKELSKEDLSPA
FDHSPNKIMTEKYNGNRIGLEEEKLTGDRCTGLSSKMQDTMEENSESALRKRIREDRKAT
TAQKVQQMKQRLNENERKRKRWLYWQPILTKMGFMSVILVGAFVGWTLFFQQNAL
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| BDBM50219567 |
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| n/a |
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| Name | BDBM50219567 |
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| Synonyms: | 4-bromo-3-(carboxymethoxy)-5-[3-({1-[(2-methylbenzyl)sulfonyl]piperidin-4-yl}amino)phenyl]thiophene-2-carboxylic acid | CHEMBL390245 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H27BrN2O7S2 |
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| Mol. Mass. | 623.536 |
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| SMILES | Cc1ccccc1CS(=O)(=O)N1CCC(CC1)Nc1cccc(c1)-c1sc(C(O)=O)c(OCC(O)=O)c1Br |
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| Structure | 
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