| Reaction Details |
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 | Report a problem with these data |
| Target | Delta-type opioid receptor |
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| Ligand | BDBM50219928 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_449062 (CHEMBL898267) |
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| Ki | 3458±n/a nM |
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| Citation |  Takeuchi, K; Holloway, WG; McKinzie, JH; Suter, TM; Statnick, MA; Surface, PL; Emmerson, PJ; Thomas, EM; Siegel, MG; Matt, JE; Wolfe, CN; Mitch, CH Structure-activity relationship studies of carboxamido-biaryl ethers as opioid receptor antagonists (OpRAs). Part 1. Bioorg Med Chem Lett17:5349-52 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Delta-type opioid receptor |
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| Name: | Delta-type opioid receptor |
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| Synonyms: | D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 40382.98 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor. |
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| Residue: | 372 |
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| Sequence: | MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVC
AVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL
CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG
VPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL
RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAAL
HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTAC
TPSDGPGGGAAA
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| BDBM50219928 |
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| n/a |
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| Name | BDBM50219928 |
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| Synonyms: | CHEMBL238282 | N-methyl-6-[4-(phenethylamino-methyl)-phenoxy]-nicotinamidine |
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| Type | Small organic molecule |
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| Emp. Form. | C22H24N4O |
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| Mol. Mass. | 360.4522 |
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| SMILES | CN=C(N)c1ccc(Oc2ccc(CNCCc3ccccc3)cc2)nc1 |w:1.0| |
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| Structure | 
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