| Reaction Details |
|---|
 | Report a problem with these data |
| Target | MAP kinase-activated protein kinase 3 |
|---|
| Ligand | BDBM50220232 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_449183 (CHEMBL899448) |
|---|
| IC50 | 4520±n/a nM |
|---|
| Citation |  Hamblett, CL; Methot, JL; Mampreian, DM; Sloman, DL; Stanton, MG; Kral, AM; Fleming, JC; Cruz, JC; Chenard, M; Ozerova, N; Hitz, AM; Wang, H; Deshmukh, SV; Nazef, N; Harsch, A; Hughes, B; Dahlberg, WK; Szewczak, AA; Middleton, RE; Mosley, RT; Secrist, JP; Miller, TA The discovery of 6-amino nicotinamides as potent and selective histone deacetylase inhibitors. Bioorg Med Chem Lett17:5300-9 (2007) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| MAP kinase-activated protein kinase 3 |
|---|
| Name: | MAP kinase-activated protein kinase 3 |
|---|
| Synonyms: | 3pK | Chromosome 3p kinase | MAP kinase-activated protein kinase 3 (MAPKAP-K3) | MAPK-Activated Protein Kinase 3 (MK3) | MAPK-activated protein kinase 3 | MAPK3_HUMAN | MAPKAP kinase 3 | MAPKAPK-3 | MAPKAPK3 |
|---|
| Type: | Serine/threonine-protein kinase |
|---|
| Mol. Mass.: | 42991.57 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Recombinant MAPKAPK3 was phosphorylated by incubation with active p38alpha before assays. |
|---|
| Residue: | 382 |
|---|
| Sequence: | MDGETAEEQGGPVPPPVAPGGPGLGGAPGGRREPKKYAVTDDYQLSKQVLGLGVNGKVLE
CFHRRTGQKCALKLLYDSPKARQEVDHHWQASGGPHIVCILDVYENMHHGKRCLLIIMEC
MEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLHSHNIAHRDVKPENLLYTSKEKD
AVLKLTDFGFAKETTQNALQTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGFP
PFYSNTGQAISPGMKRRIRLGQYGFPNPEWSEVSEDAKQLIRLLLKTDPTERLTITQFMN
HPWINQSMVVPQTPLHTARVLQEDKDHWDEVKEEMTSALATMRVDYDQVKIKDLKTSNNR
LLNKRRKKQAGSSSASQGCNNQ
|
|
|
|---|
| BDBM50220232 |
|---|
| n/a |
|---|
| Name | BDBM50220232 |
|---|
| Synonyms: | (S)-benzyl 4-(5-((2-aminophenyl)carbamoyl)pyridin-2-yl)-2-methylpiperazine-1-carboxylate | (S)-benzyl 4-(5-(2-aminophenylcarbamoyl)pyridin-2-yl)-2-methylpiperazine-1-carboxylate | CHEMBL236902 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H27N5O3 |
|---|
| Mol. Mass. | 445.5136 |
|---|
| SMILES | C[C@H]1CN(CCN1C(=O)OCc1ccccc1)c1ccc(cn1)C(=O)Nc1ccccc1N |r| |
|---|
| Structure | 
|
|---|
Search and Browse
