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TargetBeta-secretase 1
LigandBDBM50220307
Substrate/Competitorn/a
Meas. Tech.ChEMBL_449199
IC50 1890±n/a nM
Citation Fobare WFSolvibile WRRobichaud AJMalamas MSManas ETurner JHu YWagner EChopra RCowling RJin GBard J Thiophene substituted acylguanidines as BACE1 inhibitors. Bioorg Med Chem Lett 17:5353-6 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Beta-secretase 1
Name:Beta-secretase 1
Synonyms:ASP2 | Asp 2 | Aspartyl protease 2 | BACE | BACE1 | Beta-secretase 1 (BACE 1) | Beta-secretase 1 (BACE-1) | Beta-secretase 1 (BACE1) | Beta-site APP cleaving enzyme 1 | Beta-site amyloid precursor protein cleaving enzyme 1 | KIAA1149 | Memapsin-2 | Membrane-associated aspartic protease 2 | beta-Secretase (BACE-1) | beta-Secretase (BACE1)
Type:Protein
Mol. Mass.:55755.10
Organism:Homo sapiens (Human)
Description:P56817
Residue:501
Sequence:
MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF
VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST
YRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGIL
GLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGI
DHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKK
VFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRIT
ILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSAC
HVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQW
RCLRCLRQQHDDFADDISLLK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50220307
n/a
NameBDBM50220307
Synonyms:CHEMBL237061 | N-(diaminomethylene)-2-(2-phenyl-4-(4-propoxyphenyl)thiophen-3-yl)acetamide
TypeSmall organic molecule
Emp. Form.C22H23N3O2S
Mol. Mass.393.502
SMILESCCCOc1ccc(cc1)-c1csc(c1CC(=O)NC(N)=N)-c1ccccc1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: