Reaction Details |
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Target | Beta-secretase 1 |
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Ligand | BDBM50220315 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_449199 (CHEMBL899464) |
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IC50 | 680±n/a nM |
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Citation | Fobare, WF; Solvibile, WR; Robichaud, AJ; Malamas, MS; Manas, E; Turner, J; Hu, Y; Wagner, E; Chopra, R; Cowling, R; Jin, G; Bard, J Thiophene substituted acylguanidines as BACE1 inhibitors. Bioorg Med Chem Lett17:5353-6 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Beta-secretase 1 |
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Name: | Beta-secretase 1 |
Synonyms: | ASP2 | Asp 2 | Aspartyl protease 2 | BACE | BACE1 | BACE1_HUMAN | Beta-secretase (BACE) | Beta-secretase 1 | Beta-secretase 1 (BACE 1) | Beta-secretase 1 (BACE-1) | Beta-secretase 1 (BACE1) | Beta-site APP cleaving enzyme 1 | Beta-site amyloid precursor protein cleaving enzyme 1 | KIAA1149 | Memapsin-2 | Membrane-associated aspartic protease 2 | beta-Secretase (BACE-1) | beta-Secretase (BACE1) |
Type: | Protein |
Mol. Mass.: | 55755.10 |
Organism: | Homo sapiens (Human) |
Description: | P56817 |
Residue: | 501 |
Sequence: | MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF
VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST
YRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGIL
GLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGI
DHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKK
VFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRIT
ILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSAC
HVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQW
RCLRCLRQQHDDFADDISLLK
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BDBM50220315 |
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n/a |
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Name | BDBM50220315 |
Synonyms: | CHEMBL236852 | N-(diaminomethylene)-2-(4-phenyl-2-(4-propoxyphenyl)thiophen-3-yl)acetamide |
Type | Small organic molecule |
Emp. Form. | C22H23N3O2S |
Mol. Mass. | 393.502 |
SMILES | CCCOc1ccc(cc1)-c1scc(c1CC(=O)NC(N)=N)-c1ccccc1 |
Structure |
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