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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Glutamate receptor ionotropic, NMDA 2B | ||
| Ligand | BDBM50220595 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_457343 (CHEMBL940934) | ||
| Ki | 8.5±n/a nM | ||
| Citation |  Kawai, M; Sakurada, I; Morita, A; Iwamuro, Y; Ando, K; Omura, H; Sakakibara, S; Masuda, T; Koike, H; Honma, T; Hattori, K; Takashima, T; Mizuno, K; Mizutani, M; Kawamura, M Structure-activity relationship study of novel NR2B-selective antagonists with arylamides to avoid reactive metabolites formation. Bioorg Med Chem Lett17:5537-42 (2007) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Glutamate receptor ionotropic, NMDA 2B | |||
| Name: | Glutamate receptor ionotropic, NMDA 2B | ||
| Synonyms: | GluN2B | Glutamate [NMDA] receptor subunit epsilon 2 | Grin2b | N-methyl D-aspartate receptor subtype 2B | NMDA receptor subunit N2B (GluN2B) | NMDAR2B | NMDE2_RAT | NR2B | ||
| Type: | Protein | ||
| Mol. Mass.: | 166077.66 | ||
| Organism: | Rattus norvegicus (Rat) | ||
| Description: | Q00960 | ||
| Residue: | 1482 | ||
| Sequence: |
| ||
| BDBM50220595 | |||
| n/a | |||
| Name | BDBM50220595 | ||
| Synonyms: | 3,5-difluoro-4-hydroxy-N-(((1s,4s)-4-(2-phenoxyethyl)cyclohexyl)methyl)benzamide | CHEMBL249311 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H25F2NO3 | ||
| Mol. Mass. | 389.4356 | ||
| SMILES | Oc1c(F)cc(cc1F)C(=O)NC[C@@H]1CC[C@H](CCOc2ccccc2)CC1 |wU:13.13,16.17,(13.63,-21.21,;14.96,-20.43,;14.96,-18.89,;13.62,-18.13,;16.29,-18.12,;17.63,-18.89,;17.63,-20.42,;16.31,-21.2,;16.32,-22.74,;18.96,-18.12,;18.95,-16.58,;20.29,-18.88,;21.62,-18.11,;22.96,-18.88,;22.96,-20.42,;24.29,-21.18,;25.62,-20.42,;26.95,-21.19,;28.29,-20.42,;29.62,-21.19,;30.95,-20.42,;32.29,-21.2,;33.62,-20.43,;33.62,-18.89,;32.28,-18.12,;30.95,-18.89,;25.62,-18.88,;24.29,-18.1,)| | ||
| Structure | 
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