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TargetHydroxycarboxylic acid receptor 2
LigandBDBM50220847
Substrate/Competitorn/a
Meas. Tech.ChEMBL_449367 (CHEMBL899634)
EC50>1000±n/a nM
Citation Skinner, PJCherrier, MCWebb, PJShin, YJGharbaoui, TLindstrom, AHong, VTamura, SYDang, HTPride, CCChen, RRichman, JGConnolly, DTSemple, G Fluorinated pyrazole acids are agonists of the high affinity niacin receptor GPR109a. Bioorg Med Chem Lett17:5620-3 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Hydroxycarboxylic acid receptor 2
Name:Hydroxycarboxylic acid receptor 2
Synonyms:G-protein coupled receptor 109A | G-protein coupled receptor HM74A | GPR109A | HCA2 | HCAR2 | HCAR2_HUMAN | HM74A | Hydroxycarboxylic acid receptor 2 | NIACR1 | Niacin Receptor GPR109A | Nicotinic acid receptor 1
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:41868.22
Organism:Homo sapiens (Human)
Description:Membranes from CHO cells expressing the recombinant human GPR109A were used in competition binding assay.
Residue:363
Sequence:
MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWK
SSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTV
VAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSF
SICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVF
VICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPS
FPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGP
TSP
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  Blast E-value cutoff:
BDBM50220847
n/a
NameBDBM50220847
Synonyms:5-ethyl-4-fluoro-1H-pyrazole-3-carboxylic acid | CHEMBL396864
TypeSmall organic molecule
Emp. Form.C6H7FN2O2
Mol. Mass.158.1304
SMILESCCc1[nH]nc(C(O)=O)c1F
Structure
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