| Reaction Details |
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 | Report a problem with these data |
| Target | Hydroxycarboxylic acid receptor 3 |
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| Ligand | BDBM50220853 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_449369 (CHEMBL899636) |
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| EC50 | 3230±n/a nM |
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| Citation |  Skinner, PJ; Cherrier, MC; Webb, PJ; Shin, YJ; Gharbaoui, T; Lindstrom, A; Hong, V; Tamura, SY; Dang, HT; Pride, CC; Chen, R; Richman, JG; Connolly, DT; Semple, G Fluorinated pyrazole acids are agonists of the high affinity niacin receptor GPR109a. Bioorg Med Chem Lett17:5620-3 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Hydroxycarboxylic acid receptor 3 |
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| Name: | Hydroxycarboxylic acid receptor 3 |
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| Synonyms: | G-protein coupled receptor 109B | G-protein coupled receptor HM74 | G-protein coupled receptor HM74B | GPR109B | HCA3 | HCAR3 | HCAR3_HUMAN | HM74 nicotinic acid GPCR | HM74B | Hydroxycarboxylic acid receptor 3 | NIACR2 | Niacin receptor 2 | Nicotinic acid receptor 2 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 44498.06 |
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| Organism: | Homo sapiens (Human) |
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| Description: | GPR109B 0 HUMAN::P49019 |
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| Residue: | 387 |
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| Sequence: | MNRHHLQDHFLEIDKKNCCVFRDDFIAKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWK
SSRIFLFNLAVADFLLIICLPFVMDYYVRRSDWKFGDIPCRLVLFMFAMNRQGSIIFLTV
VAVDRYFRVVHPHHALNKISNWTAAIISCLLWGITVGLTVHLLKKKLLIQNGTANVCISF
SICHTFRWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVF
VICFLPSVVVRIHIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPS
FPNFFSTLINRCLQRKITGEPDNNRSTSVELTGDPNKTRGAPEALIANSGEPWSPSYLGP
TSNNHSKKGHCHQEPASLEKQLGCCIE
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| BDBM50220853 |
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| n/a |
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| Name | BDBM50220853 |
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| Synonyms: | 5-(5-cyclopropyl-1H-pyrazol-3-yl)-1H-tetrazole | CHEMBL235230 |
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| Type | Small organic molecule |
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| Emp. Form. | C7H8N6 |
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| Mol. Mass. | 176.1786 |
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| SMILES | C1CC1c1cc(n[nH]1)-c1nnn[nH]1 |
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| Structure | 
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