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TargetSerine/threonine-protein kinase Chk1
LigandBDBM50220884
Substrate/Competitorn/a
Meas. Tech.ChEMBL_457438 (CHEMBL941010)
IC50 3.2±n/a nM
Citation Brnardic, EJGarbaccio, RMFraley, METasber, ESSteen, JTArrington, KLDudkin, VYHartman, GDStirdivant, SMDrakas, BARickert, KWalsh, ESHamilton, KBuser, CAHardwick, JTao, WBeck, SCMao, XLobell, RBSepp-Lorenzino, LYan, YIkuta, MMunshi, SKKuo, LCKreatsoulas, C Optimization of a pyrazoloquinolinone class of Chk1 kinase inhibitors. Bioorg Med Chem Lett17:5989-94 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Serine/threonine-protein kinase Chk1
Name:Serine/threonine-protein kinase Chk1
Synonyms:CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1)
Type:Enzyme Catalytic Domain
Mol. Mass.:54443.02
Organism:Homo sapiens (Human)
Description:gi_166295192
Residue:476
Sequence:
MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINK
MLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVY
LHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK
RREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLA
LLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDF
SPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLL
GTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRR
NNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50220884
n/a
NameBDBM50220884
Synonyms:(S)-5-(3-amino-2-fluoropropyl)-7,8-dicyclohexyl-3-methyl-2H-pyrazolo[4,3-c]quinolin-4(5H)-one | CHEMBL249177
TypeSmall organic molecule
Emp. Form.C26H35FN4O
Mol. Mass.438.5807
SMILESCc1[nH]nc2c1c(=O)n(C[C@@H](F)CN)c1cc(C3CCCCC3)c(cc21)C1CCCCC1
Structure
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