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TargetMelanocortin receptor 4
LigandBDBM50221116
Substrate/Competitorn/a
Meas. Tech.ChEMBL_449484 (CHEMBL899759)
Ki 8.7±n/a nM
Citation Jiang, WTucci, FCTran, JAFleck, BAWen, JMarkison, SMarinkovic, DChen, CWArellano, MHoare, SRJohns, MFoster, ACSaunders, JChen, C Pyrrolidinones as potent functional antagonists of the human melanocortin-4 receptor. Bioorg Med Chem Lett17:5610-3 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Melanocortin receptor 4
Name:Melanocortin receptor 4
Synonyms:MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R)
Type:Enzyme
Mol. Mass.:36949.50
Organism:Homo sapiens (Human)
Description:P32245
Residue:332
Sequence:
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVS
GILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGAN
MKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL
IYALRSQELRKTFKEIICCYPLGGLCDLSSRY
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  Blast E-value cutoff:
BDBM50221116
n/a
NameBDBM50221116
Synonyms:1-((R)-3-(2,4-dichlorophenyl)-1-(4-(2-((S)-1-(2-hydroxyethylamino)-3-methylbutyl)-4-(trifluoromethyl)phenyl)piperazin-1-yl)-1-oxopropan-2-yl)pyrrolidin-2-one | CHEMBL396884
TypeSmall organic molecule
Emp. Form.C31H39Cl2F3N4O3
Mol. Mass.643.568
SMILESCC(C)C[C@H](NCCO)c1cc(ccc1N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1Cl)N1CCCC1=O)C(F)(F)F
Structure
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