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TargetMelanocortin receptor 4
LigandBDBM50221109
Substrate/Competitorn/a
Meas. Tech.ChEMBL_449484 (CHEMBL899759)
Ki 0.710000±n/a nM
Citation Jiang, WTucci, FCTran, JAFleck, BAWen, JMarkison, SMarinkovic, DChen, CWArellano, MHoare, SRJohns, MFoster, ACSaunders, JChen, C Pyrrolidinones as potent functional antagonists of the human melanocortin-4 receptor. Bioorg Med Chem Lett17:5610-3 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Melanocortin receptor 4
Name:Melanocortin receptor 4
Synonyms:MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R)
Type:Enzyme
Mol. Mass.:36949.50
Organism:Homo sapiens (Human)
Description:P32245
Residue:332
Sequence:
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVS
GILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGAN
MKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL
IYALRSQELRKTFKEIICCYPLGGLCDLSSRY
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50221109
n/a
NameBDBM50221109
Synonyms:(R)-2-amino-N-((S)-1-(2-(4-((R)-3-(2,4-dichlorophenyl)-2-(2-oxopyrrolidin-1-yl)propanoyl)piperazin-1-yl)-5-methylphenyl)-3-methylbutyl)propanamide | CHEMBL262321
TypeSmall organic molecule
Emp. Form.C32H43Cl2N5O3
Mol. Mass.616.622
SMILESCC(C)C[C@H](NC(=O)[C@@H](C)N)c1cc(C)ccc1N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1Cl)N1CCCC1=O
Structure
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