Reaction Details |
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Target | Proteinase-activated receptor 1 |
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Ligand | BDBM50222013 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_446321 (CHEMBL895431) |
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IC50 | 19±n/a nM |
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Citation | Chelliah, MV; Chackalamannil, S; Xia, Y; Eagen, K; Clasby, MC; Gao, X; Greenlee, W; Ahn, HS; Agans-Fantuzzi, J; Boykow, G; Hsieh, Y; Bryant, M; Palamanda, J; Chan, TM; Hesk, D; Chintala, M Heterotricyclic himbacine analogs as potent, orally active thrombin receptor (protease activated receptor-1) antagonists. J Med Chem50:5147-60 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Proteinase-activated receptor 1 |
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Name: | Proteinase-activated receptor 1 |
Synonyms: | CF2R | Coagulation factor II receptor | F2R | PAR-1 | PAR1 | PAR1_HUMAN | Proteinase activated receptor 1 | Proteinase-activated receptor 1 (PAR-1) | TR | Thrombin receptor | Thrombin receptor/ Proteinase-activated receptor 1(Par-1) |
Type: | Protein |
Mol. Mass.: | 47450.07 |
Organism: | Homo sapiens (Human) |
Description: | P25116 |
Residue: | 425 |
Sequence: | MGPRRLLLVAACFSLCGPLLSARTRARRPESKATNATLDPRSFLLRNPNDKYEPFWEDEE
KNESGLTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPLN
IMAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELCRFVTA
AFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGRASFTCLAIWALAIAGVVPLLLK
EQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCLSSS
AVANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAHYSFLSHTSTTEAAYFAYLLCVCVS
SISCCIDPLIYYYASSECQRYVYSILCCKESSDPSSYNSSGQLMASKMDTCSSNLNNSIY
KKLLT
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BDBM50222013 |
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n/a |
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Name | BDBM50222013 |
Synonyms: | (1R,3aR,4aS,8aS,9S,9aS)-9-[(E)-2-[5-(3-chlorophenyl)-2-pyridinyl]ethenyl]-decahydro-1-methyl-3H-furo[3,4-g][2]benzopyran-3-one | CHEMBL244103 |
Type | Small organic molecule |
Emp. Form. | C25H26ClNO3 |
Mol. Mass. | 423.932 |
SMILES | C[C@H]1OC(=O)[C@@H]2C[C@@H]3COCC[C@H]3[C@H](\C=C\c3ccc(cn3)-c3cccc(Cl)c3)[C@H]12 |
Structure |
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