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TargetProteinase-activated receptor 1
LigandBDBM50222013
Substrate/Competitorn/a
Meas. Tech.ChEMBL_446321 (CHEMBL895431)
IC50 19±n/a nM
Citation Chelliah, MVChackalamannil, SXia, YEagen, KClasby, MCGao, XGreenlee, WAhn, HSAgans-Fantuzzi, JBoykow, GHsieh, YBryant, MPalamanda, JChan, TMHesk, DChintala, M Heterotricyclic himbacine analogs as potent, orally active thrombin receptor (protease activated receptor-1) antagonists. J Med Chem50:5147-60 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Proteinase-activated receptor 1
Name:Proteinase-activated receptor 1
Synonyms:CF2R | Coagulation factor II receptor | F2R | PAR-1 | PAR1 | PAR1_HUMAN | Proteinase activated receptor 1 | Proteinase-activated receptor 1 (PAR-1) | TR | Thrombin receptor | Thrombin receptor/ Proteinase-activated receptor 1(Par-1)
Type:Protein
Mol. Mass.:47450.07
Organism:Homo sapiens (Human)
Description:P25116
Residue:425
Sequence:
MGPRRLLLVAACFSLCGPLLSARTRARRPESKATNATLDPRSFLLRNPNDKYEPFWEDEE
KNESGLTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPLN
IMAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELCRFVTA
AFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGRASFTCLAIWALAIAGVVPLLLK
EQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCLSSS
AVANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAHYSFLSHTSTTEAAYFAYLLCVCVS
SISCCIDPLIYYYASSECQRYVYSILCCKESSDPSSYNSSGQLMASKMDTCSSNLNNSIY
KKLLT
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  Blast E-value cutoff:
BDBM50222013
n/a
NameBDBM50222013
Synonyms:(1R,3aR,4aS,8aS,9S,9aS)-9-[(E)-2-[5-(3-chlorophenyl)-2-pyridinyl]ethenyl]-decahydro-1-methyl-3H-furo[3,4-g][2]benzopyran-3-one | CHEMBL244103
TypeSmall organic molecule
Emp. Form.C25H26ClNO3
Mol. Mass.423.932
SMILESC[C@H]1OC(=O)[C@@H]2C[C@@H]3COCC[C@H]3[C@H](\C=C\c3ccc(cn3)-c3cccc(Cl)c3)[C@H]12
Structure
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