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TargetPolyunsaturated fatty acid lipoxygenase ALOX15
LigandBDBM50222308
Substrate/Competitorn/a
Meas. Tech.ChEMBL_457825 (CHEMBL924095)
IC50 8300±n/a nM
Citation Vasquez-Martinez, YOhri, RVKenyon, VHolman, TRSepúlveda-Boza, S Structure-activity relationship studies of flavonoids as potent inhibitors of human platelet 12-hLO, reticulocyte 15-hLO-1, and prostate epithelial 15-hLO-2. Bioorg Med Chem15:7408-25 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Polyunsaturated fatty acid lipoxygenase ALOX15
Name:Polyunsaturated fatty acid lipoxygenase ALOX15
Synonyms:15-Lipoxygenase-1 (15-LOX-1) | ALOX15 | Arachidonate 15-lipoxygenase | Arachidonate 15-lipoxygenase-1 | LOG15 | LOX15_HUMAN | Reticulocyte 15-lipoxygenase-1 | Sphingosine 1-phosphate receptor 1 (S1P1)
Type:Protein
Mol. Mass.:74804.05
Organism:Homo sapiens (Human)
Description:n/a
Residue:662
Sequence:
MGLYRIRVSTGASLYAGSNNQVQLWLVGQHGEAALGKRLWPARGKETELKVEVPEYLGPL
LFVKLRKRHLLKDDAWFCNWISVQGPGAGDEVRFPCYRWVEGNGVLSLPEGTGRTVGEDP
QGLFQKHREEELEERRKLYRWGNWKDGLILNMAGAKLYDLPVDERFLEDKRVDFEVSLAK
GLADLAIKDSLNVLTCWKDLDDFNRIFWCGQSKLAERVRDSWKEDALFGYQFLNGANPVV
LRRSAHLPARLVFPPGMEELQAQLEKELEGGTLFEADFSLLDGIKANVILCSQQHLAAPL
VMLKLQPDGKLLPMVIQLQLPRTGSPPPPLFLPTDPPMAWLLAKCWVRSSDFQLHELQSH
LLRGHLMAEVIVVATMRCLPSIHPIFKLIIPHLRYTLEINVRARTGLVSDMGIFDQIMST
GGGGHVQLLKQAGAFLTYSSFCPPDDLADRGLLGVKSSFYAQDALRLWEIIYRYVEGIVS
LHYKTDVAVKDDPELQTWCREITEIGLQGAQDRGFPVSLQARDQVCHFVTMCIFTCTGQH
ASVHLGQLDWYSWVPNAPCTMRLPPPTTKDATLETVMATLPNFHQASLQMSITWQLGRRQ
PVMVAVGQHEEEYFSGPEPKAVLKKFREELAALDKEIEIRNAKLDMPYEYLRPSVVENSV
AI
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  Blast E-value cutoff:
BDBM50222308
n/a
NameBDBM50222308
Synonyms:7,8-dihydroxy-30-trifluoromethylisoflavone | CHEMBL238844
TypeSmall organic molecule
Emp. Form.C16H9F3O4
Mol. Mass.322.2355
SMILESOc1ccc2c(occ(-c3cccc(c3)C(F)(F)F)c2=O)c1O
Structure
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