| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Urease |
|---|
| Ligand | BDBM50223160 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_458108 (CHEMBL924370) |
|---|
| Ki | 255±n/a nM |
|---|
| Citation |  Sivapriya, K; Suguna, P; Banerjee, A; Saravanan, V; Rao, DN; Chandrasekaran, S Facile one-pot synthesis of thio and selenourea derivatives: a new class of potent urease inhibitors. Bioorg Med Chem Lett17:6387-91 (2007) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Urease |
|---|
| Name: | Urease |
|---|
| Synonyms: | UREA_CANEN | Urea amidohydrolase |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 90746.20 |
|---|
| Organism: | Canavalia ensiformis (Jack bean) (Horse bean) |
|---|
| Description: | P07374 |
|---|
| Residue: | 840 |
|---|
| Sequence: | MKLSPREVEKLGLHNAGYLAQKRLARGVRLNYTEAVALIASQIMEYARDGEKTVAQLMCL
GQHLLGRRQVLPAVPHLLNAVQVEATFPDGTKLVTVHDPISRENGELQEALFGSLLPVPS
LDKFAETKEDNRIPGEILCEDECLTLNIGRKAVILKVTSKGDRPIQVGSHYHFIEVNPYL
TFDRRKAYGMRLNIAAGTAVRFEPGDCKSVTLVSIEGNKVIRGGNAIADGPVNETNLEAA
MHAVRSKGFGHEEEKDASEGFTKEDPNCPFNTFIHRKEYANKYGPTTGDKIRLGDTNLLA
EIEKDYALYGDECVFGGGKVIRDGMGQSCGHPPAISLDTVITNAVIIDYTGIIKADIGIK
DGLIASIGKAGNPDIMNGVFSNMIIGANTEVIAGEGLIVTAGAIDCHVHYICPQLVYEAI
SSGITTLVGGGTGPAAGTRATTCTPSPTQMRLMLQSTDDLPLNFGFTGKGSSSKPDELHE
IIKAGAMGLKLHEDWGSTPAAIDNCLTIAEHHDIQINIHTDTLNEAGFVEHSIAAFKGRT
IHTYHSEGAGGGHAPDIIKVCGIKNVLPSSTNPTRPLTSNTIDEHLDMLMVCHHLDREIP
EDLAFAHSRIRKKTIAAEDVLNDIGAISIISSDSQAMGRVGEVISRTWQTADKMKAQTGP
LKCDSSDNDNFRIRRYIAKYTINPAIANGFSQYVGSVEVGKLADLVMWKPSFFGTKPEMV
IKGGMVAWADIGDPNASIPTPEPVKMRPMYGTLGKAGGALSIAFVSKAALDQRVNVLYGL
NKRVEAVSNVRKLTKLDMKLNDALPEITVDPESYTVKADGKLLCVSEATTVPLSRNYFLF
|
|
|
|---|
| BDBM50223160 |
|---|
| n/a |
|---|
| Name | BDBM50223160 |
|---|
| Synonyms: | 3-(4-bromophenyl)-1,1-dimethylthiourea | CHEMBL249923 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C9H11BrN2S |
|---|
| Mol. Mass. | 259.166 |
|---|
| SMILES | CN(C)C(=S)Nc1ccc(Br)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
