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TargetUrease
LigandBDBM50223161
Substrate/Competitorn/a
Meas. Tech.ChEMBL_458108
Ki 25±n/a nM
Citation Sivapriya KSuguna PBanerjee ASaravanan VRao DNChandrasekaran S Facile one-pot synthesis of thio and selenourea derivatives: a new class of potent urease inhibitors. Bioorg Med Chem Lett 17:6387-91 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Urease
Name:Urease
Synonyms:Urea amidohydrolase
Type:Enzyme
Mol. Mass.:90746.20
Organism:Canavalia ensiformis (Jack bean) (Horse bean)
Description:P07374
Residue:840
Sequence:
MKLSPREVEKLGLHNAGYLAQKRLARGVRLNYTEAVALIASQIMEYARDGEKTVAQLMCL
GQHLLGRRQVLPAVPHLLNAVQVEATFPDGTKLVTVHDPISRENGELQEALFGSLLPVPS
LDKFAETKEDNRIPGEILCEDECLTLNIGRKAVILKVTSKGDRPIQVGSHYHFIEVNPYL
TFDRRKAYGMRLNIAAGTAVRFEPGDCKSVTLVSIEGNKVIRGGNAIADGPVNETNLEAA
MHAVRSKGFGHEEEKDASEGFTKEDPNCPFNTFIHRKEYANKYGPTTGDKIRLGDTNLLA
EIEKDYALYGDECVFGGGKVIRDGMGQSCGHPPAISLDTVITNAVIIDYTGIIKADIGIK
DGLIASIGKAGNPDIMNGVFSNMIIGANTEVIAGEGLIVTAGAIDCHVHYICPQLVYEAI
SSGITTLVGGGTGPAAGTRATTCTPSPTQMRLMLQSTDDLPLNFGFTGKGSSSKPDELHE
IIKAGAMGLKLHEDWGSTPAAIDNCLTIAEHHDIQINIHTDTLNEAGFVEHSIAAFKGRT
IHTYHSEGAGGGHAPDIIKVCGIKNVLPSSTNPTRPLTSNTIDEHLDMLMVCHHLDREIP
EDLAFAHSRIRKKTIAAEDVLNDIGAISIISSDSQAMGRVGEVISRTWQTADKMKAQTGP
LKCDSSDNDNFRIRRYIAKYTINPAIANGFSQYVGSVEVGKLADLVMWKPSFFGTKPEMV
IKGGMVAWADIGDPNASIPTPEPVKMRPMYGTLGKAGGALSIAFVSKAALDQRVNVLYGL
NKRVEAVSNVRKLTKLDMKLNDALPEITVDPESYTVKADGKLLCVSEATTVPLSRNYFLF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50223161
n/a
NameBDBM50223161
Synonyms:1-cyclohexyl-1-isopropyl-3,3-dimethylselenourea | CHEMBL399930
TypeSmall organic molecule
Emp. Form.C12H24N2Se
Mol. Mass.275.29
SMILESCC(C)N(C1CCCCC1)C(=[Se])N(C)C
Structure
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