Reaction Details | |||
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Target | Alpha-1A adrenergic receptor | ||
Ligand | BDBM50223565 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_450222 (CHEMBL900497) | ||
Ki | 1.2±n/a nM | ||
Citation | Chiu, G; Li, S; Cai, H; Connolly, PJ; Peng, S; Stauber, K; Pulito, V; Liu, J; Middleton, SA Aminocyclohexylsulfonamides: discovery of metabolically stable alpha(1a/1d)-selective adrenergic receptor antagonists for the treatment of benign prostatic hyperplasia/lower urinary tract symptoms (BPH/LUTS). Bioorg Med Chem Lett17:6123-8 (2007) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Alpha-1A adrenergic receptor | |||
Name: | Alpha-1A adrenergic receptor | ||
Synonyms: | ADA1A_HUMAN | ADRA1A | ADRA1C | Adrenergic alpha1A | Alpha 1A-adrenoceptor | Alpha 1A-adrenoreceptor | Alpha adrenergic receptor 1a | Alpha-1C adrenergic receptor | Alpha-adrenergic receptor 1c | Cerebral cortex alpha adrenergic receptor | adrenergic Alpha1 | adrenergic Alpha1C | ||
Type: | Cell-surface receptors | ||
Mol. Mass.: | 51511.67 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P35348 | ||
Residue: | 466 | ||
Sequence: |
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BDBM50223565 | |||
n/a | |||
Name | BDBM50223565 | ||
Synonyms: | 3,4-dimethoxy-N-((1s,4s)-4-(4-(2-(2,2,2-trifluoroethoxy)phenyl)piperazin-1-yl)cyclohexyl)benzenesulfonamide | CHEMBL438673 | ||
Type | Small organic molecule | ||
Emp. Form. | C26H34F3N3O5S | ||
Mol. Mass. | 557.625 | ||
SMILES | COc1ccc(cc1OC)S(=O)(=O)N[C@H]1CC[C@H](CC1)N1CCN(CC1)c1ccccc1OCC(F)(F)F |wU:17.21,14.14,(32.39,2.57,;30.9,2.95,;29.83,1.85,;28.32,2.24,;27.24,1.13,;27.66,-.35,;29.16,-.74,;30.24,.36,;31.73,-.03,;32.14,-1.51,;26.57,-1.45,;25.37,-.49,;27.77,-2.42,;25.74,-2.75,;24.21,-2.68,;23.38,-3.98,;21.85,-3.91,;21.13,-2.55,;21.95,-1.25,;23.49,-1.32,;19.6,-2.48,;18.78,-3.78,;17.25,-3.72,;16.54,-2.36,;17.34,-1.06,;18.89,-1.12,;15,-2.3,;14.19,-3.61,;12.64,-3.55,;11.92,-2.18,;12.74,-.88,;14.29,-.95,;15.11,.35,;14.39,1.72,;15.21,3.02,;15.97,4.36,;16.53,2.23,;13.89,3.81,)| | ||
Structure |