| Reaction Details |
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 | Report a problem with these data |
| Target | Thymidylate kinase |
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| Ligand | BDBM50223808 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_450257 (CHEMBL900534) |
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| Ki | 21000±n/a nM |
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| Citation |  Van Daele, I; Munier-Lehmann, H; Froeyen, M; Balzarini, J; Van Calenbergh, S Rational design of 5'-thiourea-substituted alpha-thymidine analogues as thymidine monophosphate kinase inhibitors capable of inhibiting mycobacterial growth. J Med Chem50:5281-92 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Thymidylate kinase |
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| Name: | Thymidylate kinase |
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| Synonyms: | KTHY_MYCTU | TMPK | Thymidine monophosphate kinase | dTMP kinase | tmk |
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| Type: | PROTEIN |
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| Mol. Mass.: | 22636.29 |
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| Organism: | Mycobacterium tuberculosis |
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| Description: | ChEMBL_208218 |
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| Residue: | 214 |
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| Sequence: | MLIAIEGVDGAGKRTLVEKLSGAFRAAGRSVATLAFPRYGQSVAADIAAEALHGEHGDLA
SSVYAMATLFALDRAGAVHTIQGLCRGYDVVILDRYVASNAAYSAARLHENAAGKAAAWV
QRIEFARLGLPKPDWQVLLAVSAELAGERSRGRAQRDPGRARDNYERDAELQQRTGAVYA
ELAAQGWGGRWLVVGADVDPGRLAATLAPPDVPS
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| BDBM50223808 |
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| n/a |
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| Name | BDBM50223808 |
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| Synonyms: | CHEMBL235478 | N-(4-chlorophenyl)-N'-[(3'-deoxythymidin-3'-yl)methyl]thiourea |
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| Type | Small organic molecule |
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| Emp. Form. | C18H21ClN4O4S |
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| Mol. Mass. | 424.902 |
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| SMILES | Cc1cn([C@H]2C[C@H](CNC(=S)Nc3ccc(Cl)cc3)[C@@H](CO)O2)c(=O)[nH]c1=O |
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| Structure | 
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