| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Thymidylate kinase |
|---|
| Ligand | BDBM50223811 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_450257 (CHEMBL900534) |
|---|
| Ki | 7200±n/a nM |
|---|
| Citation |  Van Daele, I; Munier-Lehmann, H; Froeyen, M; Balzarini, J; Van Calenbergh, S Rational design of 5'-thiourea-substituted alpha-thymidine analogues as thymidine monophosphate kinase inhibitors capable of inhibiting mycobacterial growth. J Med Chem50:5281-92 (2007) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Thymidylate kinase |
|---|
| Name: | Thymidylate kinase |
|---|
| Synonyms: | KTHY_MYCTU | TMPK | Thymidine monophosphate kinase | dTMP kinase | tmk |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 22636.29 |
|---|
| Organism: | Mycobacterium tuberculosis |
|---|
| Description: | ChEMBL_208218 |
|---|
| Residue: | 214 |
|---|
| Sequence: | MLIAIEGVDGAGKRTLVEKLSGAFRAAGRSVATLAFPRYGQSVAADIAAEALHGEHGDLA
SSVYAMATLFALDRAGAVHTIQGLCRGYDVVILDRYVASNAAYSAARLHENAAGKAAAWV
QRIEFARLGLPKPDWQVLLAVSAELAGERSRGRAQRDPGRARDNYERDAELQQRTGAVYA
ELAAQGWGGRWLVVGADVDPGRLAATLAPPDVPS
|
|
|
|---|
| BDBM50223811 |
|---|
| n/a |
|---|
| Name | BDBM50223811 |
|---|
| Synonyms: | CHEMBL235686 | N-(3,4-dichlorophenyl)-N'-[(3'-deoxythymidin-3'-yl)methyl]thiourea |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H20Cl2N4O4S |
|---|
| Mol. Mass. | 459.347 |
|---|
| SMILES | Cc1cn([C@H]2C[C@H](CNC(=S)Nc3ccc(Cl)c(Cl)c3)[C@@H](CO)O2)c(=O)[nH]c1=O |
|---|
| Structure | 
|
|---|
Search and Browse
