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TargetCathepsin K
LigandBDBM50223928
Substrate/Competitorn/a
Meas. Tech.ChEMBL_458256 (CHEMBL924502)
IC50 47±n/a nM
Citation Teno, NMiyake, TEhara, TIrie, OSakaki, JOhmori, OGunji, HMatsuura, NMasuya, KHitomi, YNonomura, KHoriuchi, MGohda, KIwasaki, AUmemura, ITada, SKometani, MIwasaki, GCowan-Jacob, SWMissbach, MLattmann, RBetschart, C Novel scaffold for cathepsin K inhibitors. Bioorg Med Chem Lett17:6096-100 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cathepsin K
Name:Cathepsin K
Synonyms:CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X
Type:Enzyme
Mol. Mass.:36975.68
Organism:Homo sapiens (Human)
Description:P43235
Residue:329
Sequence:
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIH
NLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVD
YRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGG
YMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVA
RVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGE
NWGNKGYILMARNKNNACGIANLASFPKM
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50223928
n/a
NameBDBM50223928
Synonyms:6-biphenyl-4-ylmethyl-7-cyclohexyl-7H-pyrrolo[2,3-d]pyrimidine-2-carbonitrile | CHEMBL398519
TypeSmall organic molecule
Emp. Form.C26H24N4
Mol. Mass.392.4956
SMILESN#Cc1ncc2cc(Cc3ccc(cc3)-c3ccccc3)n(C3CCCCC3)c2n1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: