| Reaction Details |
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 | Report a problem with these data |
| Target | Cathepsin K |
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| Ligand | BDBM50223923 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_458256 (CHEMBL924502) |
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| IC50 | 15±n/a nM |
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| Citation |  Teno, N; Miyake, T; Ehara, T; Irie, O; Sakaki, J; Ohmori, O; Gunji, H; Matsuura, N; Masuya, K; Hitomi, Y; Nonomura, K; Horiuchi, M; Gohda, K; Iwasaki, A; Umemura, I; Tada, S; Kometani, M; Iwasaki, G; Cowan-Jacob, SW; Missbach, M; Lattmann, R; Betschart, C Novel scaffold for cathepsin K inhibitors. Bioorg Med Chem Lett17:6096-100 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cathepsin K |
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| Name: | Cathepsin K |
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| Synonyms: | CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X |
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| Type: | Enzyme |
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| Mol. Mass.: | 36975.68 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P43235 |
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| Residue: | 329 |
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| Sequence: | MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIH
NLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVD
YRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGG
YMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVA
RVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGE
NWGNKGYILMARNKNNACGIANLASFPKM
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| BDBM50223923 |
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| n/a |
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| Name | BDBM50223923 |
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| Synonyms: | 6-benzyl-7-cyclohexyl-7H-pyrrolo[2,3-d]pyrimidine-2-carbonitrile | CHEMBL249157 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H20N4 |
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| Mol. Mass. | 316.3996 |
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| SMILES | N#Cc1ncc2cc(Cc3ccccc3)n(C3CCCCC3)c2n1 |
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| Structure | 
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