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TargetHistamine H3 receptor
LigandBDBM50224188
Substrate/Competitorn/a
Meas. Tech.ChEMBL_450591 (CHEMBL900877)
EC50 1.58±n/a nM
Citation Altenbach, RJ; Liu, H; Banfor, PN; Browman, KE; Fox, GB; Fryer, RM; Komater, VA; Krueger, KM; Marsh, K; Miller, TR; Pan, JB; Pan, L; Sun, M; Thiffault, C; Wetter, J; Zhao, C; Zhou, D; Esbenshade, TA; Hancock, AA; Cowart, MD Synthesis, potency, and in vivo profiles of quinoline containing histamine H3 receptor inverse agonists. J Med Chem50:5439-48 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Histamine H3 receptor
Name:Histamine H3 receptor
Synonyms:G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4)
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:48691.47
Organism:Homo sapiens (Human)
Description:Binding assays were using CHO cells stably expressing hH3R receptors.
Residue:445
Sequence:
MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTS
SAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAA
GPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSV
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSL
AVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFR
RAFTKLLCPQKLKIQPHSSLEHCWK
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  Blast E-value cutoff:
BDBM50224188
n/a
NameBDBM50224188
Synonyms:(R)-2-methyl-3-(6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinolin-2-yl)-1,8-naphthyridine | 2-methyl-3-{6-[2-([2R]-2-methylpyrrolidin-1-yl)-ethyl]quinolin-2-yl}-[1,8]naphthyridine | CHEMBL263101
TypeSmall organic molecule
Emp. Form.C25H26N4
Mol. Mass.382.5007
SMILESC[C@@H]1CCCN1CCc1ccc2nc(ccc2c1)-c1cc2cccnc2nc1C
Structure
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