Reaction Details |
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Target | Histamine H3 receptor |
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Ligand | BDBM50224192 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_450587 (CHEMBL900871) |
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Ki | 0.93±n/a nM |
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Citation | Altenbach, RJ; Liu, H; Banfor, PN; Browman, KE; Fox, GB; Fryer, RM; Komater, VA; Krueger, KM; Marsh, K; Miller, TR; Pan, JB; Pan, L; Sun, M; Thiffault, C; Wetter, J; Zhao, C; Zhou, D; Esbenshade, TA; Hancock, AA; Cowart, MD Synthesis, potency, and in vivo profiles of quinoline containing histamine H3 receptor inverse agonists. J Med Chem50:5439-48 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histamine H3 receptor |
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Name: | Histamine H3 receptor |
Synonyms: | HH3R | HRH3_RAT | Hrh3 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 48607.98 |
Organism: | Rattus norvegicus (rat) |
Description: | n/a |
Residue: | 445 |
Sequence: | MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCAS
SVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAG
PEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAA
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSL
AIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFR
RAFTKLLCPQKLKVQPHGSLEQCWK
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BDBM50224192 |
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n/a |
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Name | BDBM50224192 |
Synonyms: | (R)-2-(2,7-dimethylpyrazolo[1,5-a]pyrimidin-6-yl)-6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinoline | 2-(2,7-dimethylpyrazolo[1,5-a]pyrimidin-6-yl)-6-{2-[(2R)-2-methylpyrrolidin-1-yl]ethyl}quinoline | CHEMBL392573 |
Type | Small organic molecule |
Emp. Form. | C24H27N5 |
Mol. Mass. | 385.5047 |
SMILES | C[C@@H]1CCCN1CCc1ccc2nc(ccc2c1)-c1cnc2cc(C)nn2c1C |
Structure |
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