| Reaction Details |
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 | Report a problem with these data |
| Target | 11-beta-hydroxysteroid dehydrogenase 1 |
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| Ligand | BDBM50224207 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_450656 (CHEMBL900939) |
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| Ki | 140±n/a nM |
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| Citation |  Yuan, C; St Jean, DJ; Liu, Q; Cai, L; Li, A; Han, N; Moniz, G; Askew, B; Hungate, RW; Johansson, L; Tedenborg, L; Pyring, D; Williams, M; Hale, C; Chen, M; Cupples, R; Zhang, J; Jordan, S; Bartberger, MD; Sun, Y; Emery, M; Wang, M; Fotsch, C The discovery of 2-anilinothiazolones as 11beta-HSD1 inhibitors. Bioorg Med Chem Lett17:6056-61 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 11-beta-hydroxysteroid dehydrogenase 1 |
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| Name: | 11-beta-hydroxysteroid dehydrogenase 1 |
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| Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 32409.16 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P28845 |
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| Residue: | 292 |
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| Sequence: | MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAH
VVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNH
ITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMV
AAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEE
CALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
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| BDBM50224207 |
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| n/a |
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| Name | BDBM50224207 |
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| Synonyms: | 2-(2-fluorophenylamino)-5-isopropylthiazol-4(5H)-one | CHEMBL392452 | CHEMBL393908 | CHEMBL396617 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H13FN2OS |
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| Mol. Mass. | 252.308 |
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| SMILES | CC(C)c1sc(Nc2ccccc2F)nc1O |
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| Structure | 
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